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Protein basic information

LiverAtlas Protein ID

HuLPr13118

Uniprot ID

BTNL2_HUMAN

Uniprot Acc

Q9UIR0;A0PJV5;B0UYW9;B0V0N6;O98261;Q08E96;Q58R22;Q58R23;Q5JYF9;Q5MP42;Q5MP43;Q5RIF8;Q5SP08;Q5SP09;Q5SRW3;Q5SRW4;Q5SU36;Q95HK0;

Protein name

Butyrophilin-like protein 2

Comment

FUNCTION:Negative regulator of T cell proliferation (By similarity).||SUBCELLULAR LOCATION:Membrane; Single-pass type II membrane protein. Note=Isoform 2 is present in the nuclear, vesicle and plasma membranes, isoform 3 is found in cytoplasmic vesicle structures and is not membrane bound.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=6; Name=1; IsoId=Q9UIR0-1; Sequence=Displayed; Name=2; Synonyms=Long; IsoId=Q9UIR0-2; Sequence=VSP 027186, VSP 027191; Name=3; Synonyms=Short; IsoId=Q9UIR0-3; Sequence=VSP 027186, VSP 027189, VSP 027190; Name=4; IsoId=Q9UIR0-4; Sequence=VSP 027185; Note=No experimental confirmation available. Ref.5 (AAI27643) sequence is in conflict in position:150:S->G; Name=5; IsoId=Q9UIR0-5; Sequence=VSP 027184; Note=No experimental confirmation available. Ref.5 (AAI19669) sequence is in conflict in position:83:S->G; Name=6; IsoId=Q9UIR0-6; Sequence=VSP 027187, VSP 027188; Note=No experimental confirmation available;||TISSUE SPE

Subcellular localization

Membrane;Single-pass type II membrane protein.

Gene name

butyrophilin-like 2 (MHC class II associated)

Protein sequence

MVDFPGYNLSGAVASFLFILLTMKQSEDFRVIGPAHPILA GVGEDALLTCQLLPKRTTMHVEVRWYRSEPSTPVFVHRD GVEVTEMQMEEYRGWVEWIENGIAKGNVALKIHNIQPSD NGQYWCHFQDGNYCGETSLLLKVAGLGSAPSIHMEGPGE SGVQLVCTARGWFPEPQVYWEDIRGEKLLAVSEHRIQDK DGLFYAEATLVVRNASAESVSCLVHNPVLTEEKGSVISL PEKLQTELASLKVNGPSQPILVRVGEDIQLTCYLSPKAN AQSMEVRWDRSHRYPAVHVYMDGDHVAGEQMAEYRGRTV LVSDAIDEGRLTLQILSARPSDDGQYRCLFEKDDVYQEA SLDLKVVSLGSSPLITVEGQEDGEMQPMCSSDGWFPQPH VPWRDMEGKTIPSSSQALTQGSHGLFHVQTLLRVTNISA VDVTCSISIPFLGEEKIATFSLSGW

Database cross reference

RefSeq Protein accession:NP_062548
RefSeq Protein gi:9624969

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Liver Organelles;

Ontology annotation

GO-C

GO:0016021;C:integral to membrane;IEA:UniProtKB-KW.

Post-translational modification

LiverAtlas Protein ID

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr13118

PHOSPHORYLATION

91

Y

PhosphoSitePlus

11536443

LTP

N