HuLPr13184

Uniprot ID

C163B_HUMAN

Uniprot Acc

Q9NR16;C9JHR7;Q6UWC2;

Protein name

Scavenger receptor cysteine-rich type 1 protein M160

Comment

SUBCELLULAR LOCATION:Isoform 1:Cell membrane; Single-pass type I membrane protein (Probable).||SUBCELLULAR LOCATION:Isoform 2:Cell membrane; Single-pass type I membrane protein (Probable).||SUBCELLULAR LOCATION:Isoform 3:Secreted (Probable).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=M160-alpha; IsoId=Q9NR16-1; Sequence=Displayed; Name=2; Synonyms=M160-beta; IsoId=Q9NR16-2; Sequence=VSP 016877; Name=3; IsoId=Q9NR16-3; Sequence=VSP 016875, VSP 016876; Note=No experimental confirmation available;||TISSUE SPECIFICITY:Isoform 1 is highly expressed in the spleen, lymph nodes, thymus, and fetal liver and weakly expressed in bone marrow and no expression was found in peripheral blood leukocytes. Isoform 1 expression is restricted to the monocyte and macrophage cell lines. Isoform 2 is only expressed in spleen.||SIMILARITY:Contains 12 SRCR domains.

Subcellular localization

Isoform 1:Cell membrane;Single-pass type I membrane protein(Probable).

Gene name

CD163 molecule-like 1

Protein sequence

MMLPQNSWHIDFGRCCCHQNLFSAVVTCILLLNSCFLISS FNGTDLELRLVNGDGPCSGTVEVKFQGQWGTVCDDGWNT TASTVVCKQLGCPFSFAMFRFGQAVTRHGKIWLDDVSCY GNESALWECQHREWGSHNCYHGEDVGVNCYGEANLGLRL VDGNNSCSGRVEVKFQERWGTICDDGWNLNTAAVVCRQL GCPSSFISSGVVNSPAVLRPIWLDDILCQGNELALWNCR HRGWGNHDCSHNEDVTLTCYDSSDLELRLVGGTNRCMGR VELKIQGRWGTVCHHKWNNAAADVVCKQLGCGTALHFAG LPHLQSGSDVVWLDGVSCSGNESFLWDCRHSGTVNFDCL HQNDVSVICSDGADLELRLADGSNNCSGRVEVRIHEQWW TICDQNWKNEQALVVCKQLGCPFSVFGSRRAKPSNEARD IWINSISCTGNESALWDCTYDGKAKRTCFRRSDAGVICS DKADLDLRLVGAHSPCYGRLEVKYQGEWGTVCHDRWSTR NAAVVCKQLGCGKPLHVFGMTYFKEASGPIWLDDVSCIG NESNIWDCEHSGWGKHNCVHREDVIVTCSGDATWGLRLV GGSNRCSGRLEVYFQGRWGTVCDDGWNSKAAAVVCSQLD CPSSIIGMGLGNASTGYGKIWLDDVSCDGDESDLWSCRN SGWGNNDCSHSEDVGVICSDASDMELRLVGGSSRCAGKV EVNVQGAVGILCANGWGMNIAEVVCRQLECGSAIRVSRE PHFTERTLHILMSNSGCTGGEASLWDCIRWEWKQTACHL NMEASLICSAHRQPRLVGADMPCSGRVEVKHADTWRSVC DSDFSLHAANVLCRELNCGDAISLSVGDHFGKGNGLTWA EKFQCEGSETHLALCPIVQHPEDTCIHSREVGVVCSRYT DVRLVNGKSQCDGQVEINVLGHWGSLCDTHWDPEDARVL CRQLSCGTALSTTGGKYIGERSVRVWGHRFHCLGNESLL DNCQMTVLGAPPCIHGNTVSVICT

Database cross reference

RefSeq Protein accession:NP_777601
RefSeq Protein gi:50659091

HLPP validation

Yes/No

Yes

Project name

French Liver;Human Liver Organelles;

GO:0005576;C:extracellular region;IEA:UniProtKB-SubCell. GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. GO:0005886;C:plasma membrane;IEA:UniProtKB-SubCell.

GO-F

GO:0005044;F:scavenger receptor activity;IEA:InterPro.