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Protein basic information

LiverAtlas Protein ID

HuLPr13188

Uniprot ID

C1D_HUMAN

Uniprot Acc

Q13901;A8K336;D6W5F8;Q05D64;

Protein name

Nuclear nucleic acid-binding protein C1D

Comment

FUNCTION:Plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA; this function may include MPHOSPH6. Can activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA. Can induce apoptosis in a p53/TP53 dependent manner. May regulate the TRAX/TSN complex formation. Potentiates transcriptional repression by NR1D1 and THRB (By similarity).||SUBUNIT:Monomer and homodimer. Interacts with NR1D1, THRA, THRB, NCOR1 and NCOR2 (By similarity). Interacts with EXOSC10; the interaction probably mediates the association with the nuclear form of the RNA exosome. The homodimeric form interacts with TSNAX following gamma-radiation. Interacts with RAC3.||SUBCELLULAR LOCATION:Cytoplasm. Nucleus, nucleolus. Note=EXOSC10 is required for nucleolar localization.||TISSUE SPECIFICITY:Ubiquitous. Expressed at very high levels in the hippocampus, medulla oblongata, mammary gland, thyroid and salivary gland.

Subcellular localization

Cytoplasm.Nucleus, nucleolus.

Gene name

C1D nuclear receptor corepressor

Protein sequence

MAGEEINEDYPVEIHEYLSAFENSIGAVDEMLKTMMSVSR NELLQKLDPLEQAKVDLVSAYTLNSMFWVYLATQGVNPK EHPVKQELERIRVYMNRVKEITDKKKAGKLDRGAASRFV KNALWEPKSKNASKVANKGKSKS

Database cross reference

RefSeq Protein accession:NP_001177192
RefSeq Protein gi:298231253

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Liver Organelles;

Ontology annotation

GO-C

GO:0005737;C:cytoplasm;IEA:UniProtKB-SubCell. GO:0000176;C:nuclear exosome (RNase complex);TAS:UniProtKB. GO:0005730;C:nucleolus;IEA:UniProtKB-SubCell.

GO-F

GO:0003677;F:DNA binding;TAS:ProtInc. GO:0003723;F:RNA binding;IDA:UniProtKB.

GO-P

GO:0006915;P:apoptosis;IEA:UniProtKB-KW. GO:0000460;P:maturation of 5.8S rRNA;IMP:UniProtKB. GO:0006355;P:regulation of transcription, DNA-dependent;IEA:UniProtKB-KW. GO:0006351;P:transcription, DNA-dependent;IEA:UniProtKB-KW.