Protein basic information
| LiverAtlas Protein ID |
HuLPr13226 |
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Uniprot ID |
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Uniprot Acc |
Q9NZP8;Q53GX9; |
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Protein name |
Complement C1r subcomponent-like protein |
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Comment |
FUNCTION:Mediates the proteolytic cleavage of HP/haptoglobin in the endoplasmic reticulum.||SUBCELLULAR LOCATION:Secreted.||TISSUE SPECIFICITY:Highly expressed in placenta, liver, kidney, pancreas, moderately in lung, spleen, prostate, ovary, colon, and PBL, and weakly in heart, skeletal muscle, thymus, testis, and small intestine. Expressed in PC-3 (prostate adenocarcinoma) and SK-OV-3 (ovary adenocarcinoma) cells, but not in LoVo and HT-29 (colon adenocarcinoma), SMMC7721 (hepatocellular carcinoma), CaoV- 3 (ovary adenocarcinoma), HeLa (cervix epithelioid carcinoma), MCF-7 (breast adenocarcinoma), U251 (glioma) or A549 (lung carcinoma) cells. Widely expressed in myeloid leukemia cell lines, including K-562 (chronic myelogenous leukemia), THP-1 (myelomonocytic leukemia), HL-60 and NB4 (promyelocytic leukemia), and KG-1 (acute myelogenous leukemia) cells. Expressed mainly in the liver and in serum (at protein level).||INDUCTION:Up-regulated in monocytes and dendritic cells (DC) undergo |
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Subcellular localization |
Secreted. |
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Gene name |
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Related liver disease name |
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Protein sequence
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MPGPRVWGKYLWRSPHSKGCPGAMWWLLLWGVLQACPTRG SVLLAQELPQQLTSPGYPEPYGKGQESSTDIKAPEGFAV RLVFQDFDLEPSQDCAGDSVTISFVGSDPSQFCGQQGSP LGRPPGQREFVSSGRSLRLTFRTQPSSENKTAHLHKGFL ALYQTVAVNYSQPISEASRGSEAINAPGDNPAKVQNHCQ EPYYQAAAAGALTCATPGTWKDRQDGEEVLQCMPVCGRP VTPIAQNQTTLGSSRAKLGNFPWQAFTSIHGRGGGALLG DRWILTAAHTIYPKDSVSLRKNQSVNVFLGHTAIDEMLK LGNHPVHRVVVHPDYRQNESHNFSGDIALLELQHSIPLG PNVLPVCLPDNETLYRSGLLGYVSGFGMEMGWLTTELKY SRLPVAPREACNAWLQKRQRPEVFSDNMFCVGDETQRHS VCQGDSGSVYVVWDNHAHHWVATGIVSWGIGCGEGYDFY TKVLSYVDWIKGVMNGKN |
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Database cross reference |
RefSeq Protein accession:NP_057630
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Liver relevance
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HCC significant Proteins |
Yes/No |
Yes |
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Quality score |
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HLPP validation |
Yes/No |
Yes |
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Project name |
Human Fetal Liver; |
Ontology annotation
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GO-F |
GO:0004252;F:serine-type endopeptidase activity;IEA:InterPro. |
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GO-P |
GO:0006958;P:complement activation, classical pathway;IEA:UniProtKB-KW. GO:0045087;P:innate immune response;IEA:UniProtKB-KW. GO:0006508;P:proteolysis;IEA:InterPro. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr13226 |
PHOSPHORYLATION |
474 |
S |
PhosphoSitePlus |
HTP |
N |
 
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HuLPr13226 |
PHOSPHORYLATION |
475 |
Y |
PhosphoSitePlus |
LTP |
N |
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