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Protein basic information

LiverAtlas Protein ID

HuLPr13270

Uniprot ID

C4BPA_HUMAN

Uniprot Acc

P04003;

Protein name

C4b-binding protein alpha chain

Comment

FUNCTION:Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component.||SUBUNIT:Disulfide-linked complex of alpha and beta chains of 3 possible sorts:a 570 kDa complex of 7 alpha chains and 1 beta chain, a 530 kDa homoheptamer of alpha chains or a 500 kDa complex of 6 alpha chains and 1 beta chain. The central body of the alpha chain homopolymer supports tentacles, each with the binding site for C4b at the end.||INTERACTION:P13050:arp4 (xeno); NbExp=3; IntAct=EBI-978348, EBI-978341;||SUBCELLULAR LOCATION:Secreted.||TISSUE SPECIFICITY:Chylomicrons in the plasma.||SIMILARITY:Contains 8 Sushi (CCP/SCR) domains.||CAUTION:It is uncertain whether Met-1 or Met-17 is the i

Subcellular localization

Secreted.

Gene name

complement component 4 binding protein, alpha

Related liver disease name

Hepatocellular carcinoma

Protein sequence

MHPPKTPSGALHRKRKMAAWPFSRLWKVSDPILFQMTLIA ALLPAVLGNCGPPPTLSFAAPMDITLTETRFKTGTTLKY TCLPGYVRSHSTQTLTCNSDGEWVYNTFCIYKRCRHPGE LRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQ DRGVGWSHPLPQCEIVKCKPPPDIRNGRHSGEENFYAYG FSVTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTCE KITCRKPDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVLR GSSVIHCDADSKWNPSPPACEPNSCINLPDIPHASWETY PRPTKEDVYVVGTVLRYRCHPGYKPTTDEPTTVICQKNL RWTPYQGCEALCCPEPKLNNGEITQHRKSRPANHCVYFY GDEISFSCHETSRFSAICQGDGTWSPRTPSCGDICNFPP KIAHGHYKQSSSYSFFKEEIIYECDKGYILVGQAKLSCS YSHWSAPAPQCKALCRKPELVNGRLSVDKDQYVEPENVT IQCDSGYGVVGPQSITCSGNRTWYPEVPKCEWETPEGCE QVLTGKRLMQCLPNPEDVKMALEVYKLSLEIEQLELQRDSARQSTLDKEL

Database cross reference

RefSeq Protein accession:NP_000706
RefSeq Protein gi:4502503

Liver relevance

HCC significant Proteins

Yes/No

Yes

Quality score

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Liver Organelles;

Ontology annotation

GO-C

GO:0005576;C:extracellular region;NAS:UniProtKB.

GO-F

GO:0005515;F:protein binding;IPI:IntAct.

GO-P

GO:0006958;P:complement activation, classical pathway;IEA:UniProtKB-KW. GO:0045087;P:innate immune response;IEA:UniProtKB-KW.

Pathway

Pathway name

CD40/CD40L_signaling