HuLPr13271

Uniprot ID

C4BPB_HUMAN

Uniprot Acc

P20851;A5JYP8;D3DT81;Q5VVR0;Q9BS25;

Protein name

C4b-binding protein beta chain

Comment

FUNCTION:Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. It also interacts with anticoagulant protein S and with serum amyloid P component. The beta chain binds protein S.||SUBUNIT:Disulfide-linked complex of alpha and beta chains of 3 possible sorts:a 570 kDa complex of 7 alpha chains and 1 beta chain, a 530 kDa homoheptamer of alpha chains or a 500 kDa complex of 6 alpha chains and 1 beta chain. The central body of the alpha chain homopolymer supports tentacles, each with the binding site for C4b at the end.||SUBCELLULAR LOCATION:Secreted.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P20851-1; Sequence=Displayed; Name=2; IsoId=P20851-2; Sequence=VSP 022594; Note=No experimental confirmation available;||SIMILARI

Subcellular localization

Secreted.

Gene name

complement component 4 binding protein, beta

Protein sequence

MFFWCACCLMVAWRVSASDAEHCPELPPVDNSIFVAKEVE GQILGTYVCIKGYHLVGKKTLFCNASKEWDNTTTECRLG HCPDPVLVNGEFSSSGPVNVSDKITFMCNDHYILKGSNR SQCLEDHTWAPPFPICKSRDCDPPGNPVHGYFEGNNFTL GSTISYYCEDRYYLVGVQEQQCVDGEWSSALPVCKLIQE APKPECEKALLAFQESKNLCEAMENFMQQLKESGMTMEE LKYSLELKKAELKAKLL

Database cross reference

RefSeq Protein accession:NP_000707
RefSeq Protein gi:4502505

Yes/No

Yes

Evidence

BodyMap

Quality score

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;

GO:0005576;C:extracellular region;NAS:UniProtKB.

GO-P

GO:0007596;P:blood coagulation;TAS:ProtInc. GO:0006958;P:complement activation, classical pathway;IEA:UniProtKB-KW. GO:0045087;P:innate immune response;IEA:UniProtKB-KW.

FOXA1_transcription_factor_network