HuLPr14517

Uniprot ID

CALR_HUMAN

Uniprot Acc

P27797;Q6IAT4;Q9UDG2;

Protein name

Calreticulin

Comment

FUNCTION:Molecular calcium-binding chaperone promoting folding, oligomeric assembly and quality control in the ER via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export.||SUBUNIT:Monomer. Component of an EIF2 complex at least composed of CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5. Interacts with PDIA3/ERp57 (By similarity). Interacts with NR3C1 and TRIM21.||INTERACTION:P25942:CD40; NbExp=1; IntAct=EBI-1049597, EBI-525714; P78545:ELF3; NbExp=1; IntAct=EBI-1049597, EBI-1057285; P11171:EPB41; NbExp=1; IntAct=EBI-1049597, EBI-1050906; Q03518:TAP1; NbExp=1; IntAct=EBI-1049597, EBI-747259;||SUBCELLULAR LOCATION:Endoplasmic reticulum lumen. Cytoplasm, cytosol. Secreted, extracellular space, extracellular matrix. Cell surface. Note=Also found in cell surface (T cells), cytosol and extracellular mat

Subcellular localization

Endoplasmic reticulum lumen.Cytoplasm, cytosol.Secreted, extracellular space, extracellular matrix.Cell surface.

Gene name

calreticulin

Related liver disease name

Hepatocellular carcinoma

Schistosomiasis

Protein sequence

MLLSVPLLLGLLGLAVAEPAVYFKEQFLDGDGWTSRWIES KHKSDFGKFVLSSGKFYGDEEKDKGLQTSQDARFYALSA SFEPFSNKGQTLVVQFTVKHEQNIDCGGGYVKLFPNSLD QTDMHGDSEYNIMFGPDICGPGTKKVHVIFNYKGKNVLI NKDIRCKDDEFTHLYTLIVRPDNTYEVKIDNSQVESGSL EDDWDFLPPKKIKDPDASKPEDWDERAKIDDPTDSKPED WDKPEHIPDPDAKKPEDWDEEMDGEWEPPVIQNPEYKGE WKPRQIDNPDYKGTWIHPEIDNPEYSPDPSIYAYDNFGV LGLDLWQVKSGTIFDNFLITNDEAYAEEFGNETWGVTKA AEKQMKDKQDEEQRLKEEEEDKKRKEEEEAEDKEDDEDK DEDEEDEEDKEEDEEEDVPGQAKDEL

Database cross reference

RefSeq Protein accession:NP_004334
RefSeq Protein gi:4757900

HCC significant Proteins

Yes/No

Yes

Quality score

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;

GO:0005829;C:cytosol;IDA:UniProtKB. GO:0005788;C:endoplasmic reticulum lumen;IDA:UniProtKB. GO:0005615;C:extracellular space;IDA:BHF-UCL. GO:0042824;C:MHC class I peptide loading complex;ISS:BHF-UCL. GO:0005634;C:nucleus;IDA:BHF-UCL. GO:0048471;C:peri

GO-F

GO:0050681;F:androgen receptor binding;IDA:BHF-UCL. GO:0005509;F:calcium ion binding;TAS:UniProtKB. GO:0051087;F:chaperone binding;TAS:BHF-UCL. GO:0001849;F:complement component C1q binding;TAS:BHF-UCL. GO:0003677;F:DNA binding;NAS:UniProtKB. GO:00051

GO-P

GO:0007050;P:cell cycle arrest;IGI:BHF-UCL. GO:0090398;P:cellular senescence;IGI:BHF-UCL. GO:0042921;P:glucocorticoid receptor signaling pathway;TAS:BHF-UCL. GO:0045665;P:negative regulation of neuron differentiation;IDA:BHF-UCL. GO:0048387;P:negative