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Protein basic information

LiverAtlas Protein ID

HuLPr14546

Uniprot ID

CAND1_HUMAN

Uniprot Acc

Q86VP6;B2RAU3;O94918;Q6PIY4;Q8NDJ4;Q96JZ9;Q96T19;Q9BTC4;Q9H0G2;Q9P0H7;Q9UF85;

Protein name

Cullin-associated NEDD8-dissociated protein 1

Comment

FUNCTION:Enhances transcription from various types of promoters (By similarity). Regulatory protein that interferes with the assembly of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex and thereby down-regulates ubiquitination of target proteins. Prevents neddylation of CUL1 by physically blocking access to the neddylation site. Disrupts interactions between CUL1 and SKP1A and between CUL1 and F-box proteins.||SUBUNIT:Binds TBP (By similarity). Part of a complex that contains CUL1 and RBX1. Binds unneddylated CUL1, but cannot bind CUL1 once it has been neddylated. Binds CUL2, CUL3, CUL4A, CUL4B and CUL5.||INTERACTION:Q13616:CUL1; NbExp=6; IntAct=EBI-456077, EBI-359390; Q13617:CUL2; NbExp=2; IntAct=EBI-456077, EBI-456179; Q13618:CUL3; NbExp=1; IntAct=EBI-456077, EBI-456129; Q13619:CUL4A; NbExp=2; IntAct=EBI-456077, EBI-456106; Q13620:CUL4B; NbExp=1; IntAct=EBI-456077, EBI-456067; Q13620-2:CUL4B; NbExp=1; IntAct=EBI-456077, EBI-485980;||SUBCELLULAR LOCATION:Nucleus (By similar

Subcellular localization

Nucleus(By similarity).

Gene name

cullin-associated and neddylation-dissociated 1

Related liver disease name

Hepatocellular carcinoma

Protein sequence

MASASYHISNLLEKMTSSDKDFRFMATNDLMTELQKDSIK LDDDSERKVVKMILKLLEDKNGEVQNLAVKCLGPLVSKV KEYQVETIVDTLCTNMLSDKEQLRDISSIGLKTVIGELP PASSGSALAANVCKKITGRLTSAIAKQEDVSVQLEALDI MADMLSRQGGLLVNFHPSILTCLLPQLTSPRLAVRKRTI IALGHLVMSCGNIVFVDLIEHLLSELSKNDSMSTTRTYI QCIAAISRQAGHRIGEYLEKIIPLVVKFCNVDDDELREY CIQAFESFVRRCPKEVYPHVSTIINICLKYLTYDPNYNY DDEDEDENAMDADGGDDDDQGSDDEYSDDDDMSWKVRRA AAKCLDAVVSTRHEMLPEFYKTVSPALISRFKEREENVK ADVFHAYLSLLKQTRPVQSWLCDPDAMEQGETPLTMLQS QVPNIVKALHKQMKEKSVKTRQCCFNMLTELVNVLPGAL TQHIPVLVPGIIFSLNDKSSSSNLKIDALSCLYVILCNH SPQVFHPHVQALVPPVVACVGDPFYKITSEALLVTQQLV KVIRPLDQPSSFDATPYIKDLFTCTIKRLKAADIDQEVK ERAISCMGQIICNLGDNLGSDLPNTLQIFLERLKNEITR LTTVKALTLIAGSPLKIDLRPVLGEGVPILASFLRKNQR ALKLGTLSALDILIKNYSDSLTAAMIDAVLDELPPLISE SDMHVSQMAISFLTTLAKVYPSSLSKISGSILNELIGLV RSPLLQGGALSAMLDFFQALVVTGTNNLGYMDLLRMLTG PVYSQSTALTHKQSYYSIAKCVAALTRACPKEGPAVVGQ FIQDVKNSRSTDSIRLLALLSLGEVGHHIDLSGQLELKS VILEAFSSPSEEVKSAASYALGSISVGNLPEYLPFVLQE ITSQPKRQYLLLHSLKEIISSASVVGLKPYVENIWALLL KHCECAEEGTRNVVAECLGKLTLIDPETLLPRLKGYLIS GSSYARSSVVTAVKFTISDHPQPI

Database cross reference

RefSeq Protein accession:NP_060918
RefSeq Protein gi:21361794

Liver relevance

HCC significant Proteins

Yes/No

Yes

Quality score

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Fetal Liver;Human Liver Organelles;

Ontology annotation

GO-C

GO:0005634;C:nucleus;IDA:UniProtKB. GO:0000151;C:ubiquitin ligase complex;IDA:UniProtKB.

GO-F

GO:0005515;F:protein binding;IPI:UniProtKB.

GO-P

GO:0030154;P:cell differentiation;IDA:UniProtKB. GO:0043086;P:negative regulation of catalytic activity;IDA:UniProtKB. GO:0016567;P:protein ubiquitination;IDA:UniProtKB. GO:0006355;P:regulation of transcription, DNA-depende Error!!! Error!!!Go back to the login page