HuLPr14786

Uniprot ID

CC4L_HUMAN

Uniprot Acc

Q8NHW4;B2RUZ3;B7ZMA8;Q50EM1;Q50EM2;Q50EM3;Q50EM4;Q50EM5;Q50EM6;Q50EM7;Q50EM8;Q569J2;Q6NSB0;

Protein name

C-C motif chemokine 4-like

Comment

FUNCTION:Chemokine that induces chemotaxis of cells expressing CCR5 or CCR1. Inhibits HIV replication in peripheral blood monocytes that express CCR5.||SUBUNIT:Interacts with CCR5.||SUBCELLULAR LOCATION:Secreted (By similarity).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=10; Comment=CCL4L1 and CCL4L2 genes differ in their non-coding regions. Thus, alternative splicing events differ between the two genes; Name=1; IsoId=Q8NHW4-1; Sequence=Displayed; Name=2; Synonyms=CCL4L2; IsoId=Q8NHW4-2; Sequence=VSP 032633; Name=3; Synonyms=CC4L2d; IsoId=Q8NHW4-3; Sequence=VSP 032629; Name=4; Synonyms=CC4L2f; IsoId=Q8NHW4-4; Sequence=VSP 032630; Name=5; Synonyms=CC4L2b1, CC4L2b2; IsoId=Q8NHW4-5; Sequence=VSP 032631; Name=6; Synonyms=CC4L2e; IsoId=Q8NHW4-6; Sequence=VSP 032632; Name=7; Synonyms=CC4L2d2; IsoId=Q8NHW4-7; Sequence=VSP 032625; Name=8; Synonyms=CC4L1d2; IsoId=Q8NHW4-8; Sequence=VSP 032626; Name=9; Synonyms=CC4L2bd2; IsoId=Q8NHW4-9; Sequence=VSP

Subcellular localization

Secreted(By similarity).

Gene name

chemokine (C-C motif) ligand 4-like 1

Protein sequence

MKLCVTVLSLLVLVAAFCSLALSAPMGSDPPTACCFSYTA RKLPRNFVVDYYETSSLCSQPAVVFQTKRGKQVCADPSE SWVQEYVYDLELN

Database cross reference

RefSeq Protein accession:NP_001001435
RefSeq Protein gi:47824887

HLPP validation

Yes/No

Yes

Project name

Human Liver Organelles;

GO:0005615;C:extracellular space;IEA:UniProtKB-KW.

GO-F

GO:0008009;F:chemokine activity;IEA:InterPro.

GO-P

GO:0006935;P:chemotaxis;IEA:UniProtKB-KW. GO:0006955;P:immune response;IEA:InterPro. GO:0006954;P:inflammatory response;IEA:UniProtKB-KW.

TCR

IL1

IL2

Leptin

TNFalpha