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Gene, Transcriptome, Protein, Pathway or Disease. 

Protein basic information

LiverAtlas Protein ID

HuLPr14863

Uniprot ID

CCDC3_HUMAN

Uniprot Acc

Q9BQI4;Q5VYV8;

Protein name

Coiled-coil domain-containing protein 3

Comment

SUBUNIT:Homodimer (By similarity).||SUBCELLULAR LOCATION:Secreted (By similarity).||TISSUE SPECIFICITY:Expressed in umbilical vein endothelial cells (HUVEC), and at lower levels in aortic smooth muscle cells (HASMC).||INDUCTION:Up-regulated by pioglitazone and down-regulated by TNF in HUVEC.

Subcellular localization

Secreted(By similarity).

Gene name

coiled-coil domain containing 3

Protein sequence

MLRQLLLAALCLAGPPAPARACQLPSEWRPLSEGCRAELA ETIVYARVLALHPEAPGLYNHLPWQYHAGQGGLFYSAEV EMLCDQAWGSMLEVPAGSRLNLTGLGYFSCHSHTVVQDY SYFFFLRMDENYNLLPHGVNFQDAIFPDTQENRRMFSSL FQFSNCSQGQQLATFSSDWEIQEDSRLMCSSVQKALFEE EDHVKKLQQKVATLEKRNRQLRERVKKVKRSLRQARKKG RHLELANQKLSEKLAAGALPHINARGPVRPPYLRG

Database cross reference

RefSeq Protein accession:NP_113643
RefSeq Protein gi:13899293

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;

Ontology annotation

GO-C

GO:0005783;C:endoplasmic reticulum;IDA:LIFEdb. GO:0005576;C:extracellular region;IEA:UniProtKB-SubCell.

Pathway

Pathway name

TNFalpha