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Gene, Transcriptome, Protein, Pathway or Disease. 

Protein basic information

LiverAtlas Protein ID

HuLPr15035

Uniprot ID

CD70_HUMAN

Uniprot Acc

P32970;Q96J57;

Protein name

CD70 antigen

Comment

FUNCTION:Cytokine that binds to CD27. Plays a role in T-cell activation. Induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells.||SUBUNIT:Homotrimer (Probable).||SUBCELLULAR LOCATION:Membrane; Single-pass type II membrane protein.||SIMILARITY:Belongs to the tumor necrosis factor family.

Subcellular localization

Membrane;Single-pass type II membrane protein.

Gene name

CD70 molecule

Protein sequence

MPEEGSGCSVRRRPYGCVLRAALVPLVAGLVICLVVCIQR FAQAQQQLPLESLGWDVAELQLNHTGPQQDPRLYWQGGP ALGRSFLHGPELDKGQLRIHRDGIYMVHIQVTLAICSST TASRHHPTTLAVGICSPASRSISLLRLSFHQGCTIASQR LTPLARGDTLCTNLTGTLLPSRNTDETFFGVQWVRP

Database cross reference

RefSeq Protein accession:NP_001243
RefSeq Protein gi:4507605

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;

Ontology annotation

GO-C

GO:0005615;C:extracellular space;IEA:UniProtKB-KW. GO:0000299;C:integral to membrane of membrane fraction;IDA:HGNC. GO:0005887;C:integral to plasma membrane;TAS:ProtInc.

GO-F

GO:0005125;F:cytokine activity;IEA:UniProtKB-KW. GO:0002020;F:protease binding;IPI:BHF-UCL. GO:0005164;F:tumor necrosis factor receptor binding;IEA:InterPro.

GO-P

GO:0008283;P:cell proliferation;TAS:ProtInc. GO:0007267;P:cell-cell signaling;TAS:ProtInc. GO:0006955;P:immune response;IEA:InterPro. GO:0006917;P:induction of apoptosis;IDA:HGNC. GO:0007165;P:signal transduction;TAS:ProtInc.

Pathway

Pathway name

IL2

Pathway name

RANKL

Pathway name

TNFalpha