HuLPr15160

Uniprot ID

CE120_HUMAN

Uniprot Acc

Q8N960;Q6AI52;Q6AW89;Q8IWB5;Q8N9Y0;Q8NDE8;

Protein name

Centrosomal protein of 120 kDa

Comment

FUNCTION:Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors and for proper positioning of neurons during brain development. Also implicated in the migration and selfrenewal of neural progenitors. May play a role in centriole duplication during mitosis (By similarity).||SUBUNIT:Interacts with TACC2 and TACC3 (By similarity). Interacts with CCDC52 (By similarity).||SUBCELLULAR LOCATION:Cytoplasm, cytoskeleton, centrosome (By similarity). Note=Regulates the localization of TACC3 to the centrosome in neural progenitors in vivo (By similarity).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8N960-1; Sequence=Displayed; Name=2; IsoId=Q8N960-2; Sequence=VSP 035123; Name=3; IsoId=Q8N960-3; Sequence=VSP 035124, VSP 035125; Note=May be produced at very low levels due to a premature stop codon in the

Subcellular localization

Cytoplasm, cytoskeleton, centrosome(By similarity).

Gene name

centrosomal protein 120kDa

Protein sequence

MVSKSDQLLIVVSILEGRHFPKRPKHMLVVEAKFDGEQLA TDPVDHTDQPEFATELAWEIDRKALHQHRLQRTPIKLQC FALDPVTSAKETIGYIVLDLRTAQETKQAPKWYQLLSNK YTKFKSEIQISIALETDTKPPVDSFKAKGAPPRDGKVPA ILAGLDPRDIVAVLNEEGGYHQIGPAEYCTDSFIMSVTI AFATQLEQLIPCTMKLPERQPEFFFYYSLLGNDVTNEPF NDLINPNFEPERASVRIRSSVEILRVYLALQSKLQIHLC CGDQSLGSTEIPLTGLLKKGSTEINQHPVTVEGAFTLDP PNRAKQKLAPIPVELAPTVGVSVALQREGIDSQSLIELK TQNEHEPEHSKKKVLTPIKEKTLTGPKSPTVSPVPSHNQ SPPTKDDATESEVESLQYDKDTKPNPKASSSVPASLAQL VTTSNASEVASGQKIAVPATSHHFCFSIDLRSIHALEIG FPINCILRYSYPFFGSAAPIMTNPPVEVRKNMEVFLPQS YCAFDFATMPHQLQDTFLRIPLLVELWHKDKMSKDLLLG IARIQLSNILSSEKTRFLGSNGEQCWRQTYSESVPVIAA QGSNNRIADLSYTVTLEDYGLVKMREIFISDSSQGVSAV QQKPSSLPPAPCPSEIQTEPRETLEYKAALELEMWKEMQ EDIFENQLKQKELAHMQALAEEWKKRDRERESLVKKKVA EYTILEGKLQKTLIDLEKREQQLASVESELQREKKELQS ERQRNLQELQDSIRRAKEDCIHQVELERLKIKQLEEDKH RLQQQLNDAENKYKILEKEFQQFKDQQNNKPEIRLQSEI NLLTLEKVELERKLESATKSKLHYKQQWGRALKELARLK QREQESQMARLKKQQEELEQMRLRYLAAEEKDTVKTERQ ELLDIRNELNRLRQQEQKQYQDSTEIASGKKDGPHGSVL EEGLDDYLTRLIEERDTLMRTGVYNHEDRIISELDRQIREILAKSNASN

Database cross reference

RefSeq Protein accession:NP_001159698
RefSeq Protein gi:261245061

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Liver Organelles;