HuLPr15230

Uniprot ID

CENPX_HUMAN

Uniprot Acc

A8MT69;O00281;O00282;Q96DD4;Q96F51;

Protein name

Centromere protein X

Comment

FUNCTION:DNA-binding component of the FA core complex involved in DNA damage repair and genome maintenance. Recruited to forks stalled by DNA interstrand cross-links, and required for cellular resistance to such lesions. As a component of the APITD1/CENPS complex, is also essential for the stable assembly of the outer kinetchore.||SUBUNIT:Component of a discrete APITD1/CENPS complex composed of at least APITD1/CENPS and STRA13/CENPX. Belongs to the multisubunit FA complex composed of APITD1/CENPS, FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9, FANCM, FAAP24 and STRA13/CENPX. Interacts with APITD1/CENPS, FANCM and FAAP24. Binds DNA.||SUBCELLULAR LOCATION:Nucleus. Chromosome, centromere (Probable). Note=Localizes to chromatin.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=A8MT69-1; Sequence=Displayed; Name=2; Synonyms=Variant A; IsoId=A8MT69-2; Sequence=VSP 033948; Name=3; Synonyms=Variant B; IsoId=A8MT69-3; Sequence=VSP 033948, VSP 033949

Subcellular localization

Nucleus.Chromosome, centromere(Probable).

Gene name

stimulated by retinoic acid 13 homolog (mouse)

Protein sequence

MEGAGAGSGFRKELVSRLLHLHFKDDKTKVSGDALQLMVE LLKVFVVEAAVRGVRQAQAEDALRVDVDQLEKVLPQLLL DF

Database cross reference

RefSeq Protein accession:NP_659435
RefSeq Protein gi:71559139

HLPP validation

Yes/No

Yes

Project name

French Liver;Human Liver Organelles;

GO:0000775;C:chromosome, centromeric region;IEA:UniProtKB-SubCell. GO:0043240;C:Fanconi anaemia nuclear complex;IDA:UniProtKB.

GO-F

GO:0003677;F:DNA binding;IDA:UniProtKB. GO:0005515;F:protein binding;IPI:UniProtKB.

GO-P

GO:0006281;P:DNA repair;IEA:UniProtKB-KW.