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Protein basic information

LiverAtlas Protein ID

HuLPr15248

Uniprot ID

CERU_HUMAN

Uniprot Acc

P00450;Q14063;Q2PP18;Q9UKS4;

Protein name

Ceruloplasmin

Comment

FUNCTION:Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane.||CATALYTIC ACTIVITY:4 Fe(2+) + 4 H(+) + O(2) = 4 Fe(3+) + 2 H(2)O.||COFACTOR:Binds 6 copper ions per monomer.||INTERACTION:Q9NP59:SLC40A1; NbExp=1; IntAct=EBI-1220171, EBI-725153;||SUBCELLULAR LOCATION:Secreted.||TISSUE SPECIFICITY:Expressed by the liver and secreted in plasma.||DISEASE:Defects in CP are the cause of aceruloplasminemia (ACERULOP) [MIM:604290]. It is an autosomal recessive disorder of iron metabolism characterized by iron accumulation in the brain as well as visceral organs. Clinical features consist of the triad of retinal degeneration, diabetes mellitus and neurological disturbances.||DISEASE:Note=Ceruloplasmin levels are decreased in Wilson disease, in which copper cannot be incorporated into ceruloplasmin in liver because of d

Subcellular localization

Secreted.

Gene name

ceruloplasmin (ferroxidase)

Related liver disease name

Hepatocellular carcinoma

Alcoholic liver disease

Protein sequence

MKILILGIFLFLCSTPAWAKEKHYYIGIIETTWDYASDHG EKKLISVDTEHSNIYLQNGPDRIGRLYKKALYLQYTDET FRTTIEKPVWLGFLGPIIKAETGDKVYVHLKNLASRPYT FHSHGITYYKEHEGAIYPDNTTDFQRADDKVYPGEQYTY MLLATEEQSPGEGDGNCVTRIYHSHIDAPKDIASGLIGP LIICKKDSLDKEKEKHIDREFVVMFSVVDENFSWYLEDN IKTYCSEPEKVDKDNEDFQESNRMYSVNGYTFGSLPGLS MCAEDRVKWYLFGMGNEVDVHAAFFHGQALTNKNYRIDT INLFPATLFDAYMVAQNPGEWMLSCQNLNHLKAGLQAFF QVQECNKSSSKDNIRGKHVRHYYIAAEEIIWNYAPSGID IFTKENLTAPGSDSAVFFEQGTTRIGGSYKKLVYREYTD ASFTNRKERGPEEEHLGILGPVIWAEVGDTIRVTFHNKG AYPLSIEPIGVRFNKNNEGTYYSPNYNPQSRSVPPSASH VAPTETFTYEWTVPKEVGPTNADPVCLAKMYYSAVDPTK DIFTGLIGPMKICKKGSLHANGRQKDVDKEFYLFPTVFD ENESLLLEDNIRMFTTAPDQVDKEDEDFQESNKMHSMNG FMYGNQPGLTMCKGDSVVWYLFSAGNEADVHGIYFSGNT YLWRGERRDTANLFPQTSLTLHMWPDTEGTFNVECLTTD HYTGGMKQKYTVNQCRRQSEDSTFYLGERTYYIAAVEVE WDYSPQREWEKELHHLQEQNVSNAFLDKGEFYIGSKYKK VVYRQYTDSTFRVPVERKAEEEHLGILGPQLHADVGDKV KIIFKNMATRPYSIHAHGVQTESSTVTPTLPGETLTYVW KIPERSGAGTEDSACIPWAYYSTVDQVKDLYSGLIGPLI VCRRPYLKVFNPRRKLEFALLFLVFDENESWYLDDNIKT YSDHPEKVNKDDEEFIESNKMHAINGRMFGNLQGLTMHV GDEVNWYLMGMGNEIDLHTVHFHG

Database cross reference

RefSeq Protein accession:NP_000087
RefSeq Protein gi:4557485

Liver relevance

HCC significant Proteins

Yes/No

Yes

Quality score

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Fetal Liver;Human Liver Organelles;

Ontology annotation

GO-C

GO:0005615;C:extracellular space;IDA:BHF-UCL.

GO-F

GO:0051087;F:chaperone binding;IPI:BHF-UCL. GO:0004322;F:ferroxidase activity;TAS:ProtInc.

GO-P

GO:0006879;P:cellular iron ion homeostasis;TAS:Reactome. GO:0006825;P:copper ion transport;IEA:UniProtKB-KW. GO:0055114;P:oxidation-reduction process;IEA:UniProtKB-KW. GO:0055085;P:t Error!!! Error!!!Go back to the login page