Protein basic information
LiverAtlas Protein ID |
HuLPr15248 |
Uniprot ID |
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Uniprot Acc |
P00450;Q14063;Q2PP18;Q9UKS4; |
Protein name |
Ceruloplasmin |
Comment |
FUNCTION:Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane.||CATALYTIC ACTIVITY:4 Fe(2+) + 4 H(+) + O(2) = 4 Fe(3+) + 2 H(2)O.||COFACTOR:Binds 6 copper ions per monomer.||INTERACTION:Q9NP59:SLC40A1; NbExp=1; IntAct=EBI-1220171, EBI-725153;||SUBCELLULAR LOCATION:Secreted.||TISSUE SPECIFICITY:Expressed by the liver and secreted in plasma.||DISEASE:Defects in CP are the cause of aceruloplasminemia (ACERULOP) [MIM:604290]. It is an autosomal recessive disorder of iron metabolism characterized by iron accumulation in the brain as well as visceral organs. Clinical features consist of the triad of retinal degeneration, diabetes mellitus and neurological disturbances.||DISEASE:Note=Ceruloplasmin levels are decreased in Wilson disease, in which copper cannot be incorporated into ceruloplasmin in liver because of d |
Subcellular localization |
Secreted. |
Gene name |
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Related liver disease name |
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Protein sequence
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MKILILGIFLFLCSTPAWAKEKHYYIGIIETTWDYASDHG EKKLISVDTEHSNIYLQNGPDRIGRLYKKALYLQYTDET FRTTIEKPVWLGFLGPIIKAETGDKVYVHLKNLASRPYT FHSHGITYYKEHEGAIYPDNTTDFQRADDKVYPGEQYTY MLLATEEQSPGEGDGNCVTRIYHSHIDAPKDIASGLIGP LIICKKDSLDKEKEKHIDREFVVMFSVVDENFSWYLEDN IKTYCSEPEKVDKDNEDFQESNRMYSVNGYTFGSLPGLS MCAEDRVKWYLFGMGNEVDVHAAFFHGQALTNKNYRIDT INLFPATLFDAYMVAQNPGEWMLSCQNLNHLKAGLQAFF QVQECNKSSSKDNIRGKHVRHYYIAAEEIIWNYAPSGID IFTKENLTAPGSDSAVFFEQGTTRIGGSYKKLVYREYTD ASFTNRKERGPEEEHLGILGPVIWAEVGDTIRVTFHNKG AYPLSIEPIGVRFNKNNEGTYYSPNYNPQSRSVPPSASH VAPTETFTYEWTVPKEVGPTNADPVCLAKMYYSAVDPTK DIFTGLIGPMKICKKGSLHANGRQKDVDKEFYLFPTVFD ENESLLLEDNIRMFTTAPDQVDKEDEDFQESNKMHSMNG FMYGNQPGLTMCKGDSVVWYLFSAGNEADVHGIYFSGNT YLWRGERRDTANLFPQTSLTLHMWPDTEGTFNVECLTTD HYTGGMKQKYTVNQCRRQSEDSTFYLGERTYYIAAVEVE WDYSPQREWEKELHHLQEQNVSNAFLDKGEFYIGSKYKK VVYRQYTDSTFRVPVERKAEEEHLGILGPQLHADVGDKV KIIFKNMATRPYSIHAHGVQTESSTVTPTLPGETLTYVW KIPERSGAGTEDSACIPWAYYSTVDQVKDLYSGLIGPLI VCRRPYLKVFNPRRKLEFALLFLVFDENESWYLDDNIKT YSDHPEKVNKDDEEFIESNKMHAINGRMFGNLQGLTMHV GDEVNWYLMGMGNEIDLHTVHFHG |
Database cross reference |
RefSeq Protein accession:NP_000087
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Liver relevance
HCC significant Proteins |
Yes/No |
Yes |
Quality score |
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HLPP validation |
Yes/No |
Yes |
Project name |
Chinese Liver;French Liver;Human Fetal Liver;Human Liver Organelles; |
Ontology annotation
GO-C |
GO:0005615;C:extracellular space;IDA:BHF-UCL. |
GO-F |
GO:0051087;F:chaperone binding;IPI:BHF-UCL. GO:0004322;F:ferroxidase activity;TAS:ProtInc. |
GO-P |
GO:0006879;P:cellular iron ion homeostasis;TAS:Reactome. GO:0006825;P:copper ion transport;IEA:UniProtKB-KW. GO:0055114;P:oxidation-reduction process;IEA:UniProtKB-KW. GO:0055085;P:t |