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Protein basic information

LiverAtlas Protein ID

HuLPr15249

Uniprot ID

CES1P_HUMAN

Uniprot Acc

Q9UKY3;A2RRL8;B9ZVS2;

Protein name

Putative inactive carboxylesterase 4

Comment

FUNCTION:Has no esterase activity (Probable).||SUBCELLULAR LOCATION:Secreted (Potential).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9UKY3-1; Sequence=Displayed; Name=2; IsoId=Q9UKY3-2; Sequence=VSP 029004; Note=No experimental confirmation available;||TISSUE SPECIFICITY:Expressed in placenta.||SIMILARITY:Belongs to the type-B carboxylesterase/lipase family.||CAUTION:In contrast to other members of the family, it is shorter and lack the C-terminal part that contains the conserved Glu and His active sites.||CAUTION:Could be the product of a pseudogene.||SEQUENCE CAUTION:Sequence=AAF14185.1; Type=Frameshift; Positions=92, 95;

Subcellular localization

Secreted(Potential).

Gene name

carboxylesterase 1 pseudogene 1

Related liver disease name

Hepatocellular carcinoma

Protein sequence

MWLPALVLATLAASAAWAGHLSSPPLVDTLHGKVLGKFVS LEGFAQPVAVFLGIPFAKPPLGPLRFTLPQPAEPWNFVK NATSYPPMFTQDPKAGQLISELFTNRKENIPLKLSEDCL YLNIYTPADLTKKNRLPVMVWIHGGGLMVGAASTYDGLA LAAHENVVVVTIQYRLGIWGFFSTGDEHSPGNWGHLDQL AALHWVQDNIASFGGNPGSVTIFGGSVGGESVSVLVLSP LAKNLFHRAISESGVALTSVLVKKGDVKPLAEVGLRLVR LRLDTPTSLALCS

Database cross reference


Liver relevance

HCC significant Proteins

Yes/No

Yes

Quality score

HLPP validation

Yes/No

Yes

Project name

Human Liver Organelles;

Ontology annotation

GO-C

GO:0005783;C:endoplasmic reticulum;TAS:ProtInc. GO:0005576;C:extracellular region;IEA:UniProtKB-SubCell.

GO-F

GO:0004091;F:carboxylesterase activity;ISS:RefGenome.

GO-P

GO:0009653;P:anatomical structure morphogenesis;TAS:ProtInc. GO:0050804;P:regulation of synaptic transmission;ISS:RefGenome.

Pathway

Pathway name

E2F_transcription_factor_network