Protein basic information
| LiverAtlas Protein ID |
HuLPr15253 |
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Uniprot ID |
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Uniprot Acc |
P11597;Q13987;Q13988;Q53YZ1; |
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Protein name |
Cholesteryl ester transfer protein |
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Comment |
FUNCTION:Involved in the transfer of insoluble cholesteryl esters in the reverse transport of cholesterol.||SUBCELLULAR LOCATION:Secreted, extracellular space.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P11597-1; Sequence=Displayed; Name=2; IsoId=P11597-2; Sequence=VSP 023645;||TISSUE SPECIFICITY:Expressed by the liver and secreted in plasma.||DISEASE:Defects in CETP are a cause of hyperalphalipoproteinemia (HYPALIP) [MIM:143470]. Affected individuals show high levels of alpha-lipoprotein (high density lipoprotein/HDL).||DISEASE:Defects in CETP are the cause of cholesteryl ester transfer protein deficiency (CETP deficiency) [MIM:607322]. This is an autosomal dominant condition associated with increased HDL cholesterol levels.||SIMILARITY:Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.||WEB RESOURCE:Name=SHMPD; Note=The Singapore human mutation and polymorphism database; URL="http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genenam |
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Subcellular localization |
Secreted, extracellular space. |
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Gene name |
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Related liver disease name |
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Protein sequence
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MLAATVLTLALLGNAHACSKGTSHEAGIVCRITKPALLVL NHETAKVIQTAFQRASYPDITGEKAMMLLGQVKYGLHNI QISHLSIASSQVELVEAKSIDVSIQNVSVVFKGTLKYGY TTAWWLGIDQSIDFEIDSAIDLQINTQLTCDSGRVRTDA PDCYLSFHKLLLHLQGEREPGWIKQLFTNFISFTLKLVL KGQICKEINVISNIMADFVQTRAASILSDGDIGVDISLT GDPVITASYLESHHKGHFIYKNVSEDLPLPTFSPTLLGD SRMLYFWFSERVFHSLAKVAFQDGRLMLSLMGDEFKAVL ETWGFNTNQEIFQEVVGGFPSQAQVTVHCLKMPKISCQN KGVVVNSSVMVKFLFPRPDQQHSVAYTFEEDIVTTVQAS YSKKKLFLSLLDFQITPKTVSNLTESSSESVQSFLQSMI TAVGIPEVMSRLEVVFTALMNSKGVSLFDIINPEIITRD GFLLLQMDFGFPEHLLVDFLQSLS |
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Database cross reference |
RefSeq Protein accession:NP_000069
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Liver relevance
| Liver sepcificity |
Yes/No |
Yes |
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Evidence |
Translational level from literatures |
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Quality score |
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HCC significant Proteins |
Yes/No |
Yes |
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Quality score |
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HLPP validation |
Yes/No |
Yes |
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Project name |
Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0034364;C:high-density lipoprotein particle;IDA:BHF-UCL. GO:0031982;C:vesicle;IDA:BHF-UCL. |
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GO-F |
GO:0015485;F:cholesterol binding;IDA:BHF-UCL. GO:0017127;F:cholesterol transporter activity;IDA:BH |