Protein basic information
| LiverAtlas Protein ID |
HuLPr15359 |
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Uniprot ID |
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Uniprot Acc |
Q0VF96;Q05BZ4;Q52LR0;Q695C7;Q7Z2L3;Q96JV2;Q96MN6;Q9C0B4; |
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Protein name |
Cingulin-like protein 1 |
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Comment |
FUNCTION:May be involved in anchoring the apical junctional complex, especially tight junctions, to actin-based cytoskeletons (By similarity).||SUBUNIT:Homodimer or oligomer (By similarity).||SUBCELLULAR LOCATION:Cell junction, tight junction (By similarity). Note=Localizes to the apical junction complex composed of tight and adherens junctions (By similarity).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q0VF96-1; Sequence=Displayed; Name=2; IsoId=Q0VF96-2; Sequence=VSP 029946;||TISSUE SPECIFICITY:Smooth muscle, spleen, testis, fetal brain, amygdala, corpus callosum, cerebellum, thalamus and subthalamic nucleus of adult brain.||DOMAIN:The head region is responsible for junction-based distribution (By similarity).||DISEASE:A chromosomal aberration involving CGNL1 is a cause of aromatase excess syndrome [MIM:139300]. This is characterized by an estrogen excess due to an increased aromatase activity. An inversion on inv(15)(q21.2;q21.3) moves the |
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Subcellular localization |
Cell junction, tight junction(By similarity). |
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Gene name |
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Protein sequence
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MELYFGEYQHVQQEYGVHLRLASDDTQKSRSSQNSKAGSY GVSIRVQGIDGHPYIVLNNTERCLAGTSFSENGPPFPPP VINNLPLHSSNGSVPKENSEELQLPENPYAQPSPIRNLK QPLLHEGKNGVLDRKDGSVKPSHLLNFQRHPELLQPYDP EKNELNLQNHQPSESNWLKTLTEEGINNKKPWTCFPKPS NSQPTSPSLEDPAKSGVTAIRLCSSVVIEDPKKQTSVCV NVQSCTKERVGEEALFTSGRPLTAHSPHAHPETKKTRPD VLPFRRQDSAGPVLDGARSRRSSSSSTTPTSANSLYRFL LDDQECAIHADNVNRHENRRYIPFLPGTGRDIDTGSIPG VDQLIEKFDQKPGLQRRGRSGKRNRINTDDRKRSRSVDS AFPFGLQGNSEYLIEFSRNLGKSSEHLLRPSQVCPQRPL SQERRGKQSVGRTFAKLQGAAHGASCAHSRPPQPNIDGK VLETEGSQESTVIRAPSLGAQSKKEEEVKTATATLMLQN RATATSPDSGAKKISVKTFPSASNTQATPDLLKGQQELT QQTNEETAKQILYNYLKEGSTDNDDATKRKVNLVFEKIQ TLKSRAAGSAQGNNQACNSTSEVKDLLEQKSKLTIEVAE LQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEE NSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDL QDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDL LIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKL KEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGT EMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDE AKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALE NELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKN EMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLD EYKEKNRRELAEMQRQLKEKTLEA |
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Database cross reference |
RefSeq Protein accession:NP_116255
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Liver relevance
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HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0016459;C:myosin complex;IEA:InterPro. GO:0005923;C:tight junction;IEA:UniProtKB-SubCell. |
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GO-F |
GO:0003774;F:motor activity;IEA:InterPro. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr15359 |
PHOSPHORYLATION |
204 |
S |
PhosphoSitePlus |
LTP |
N |
 
|
|
|
HuLPr15359 |
PHOSPHORYLATION |
296 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr15359 |
PHOSPHORYLATION |
299 |
S |
PhosphoSitePlus |
LTP |
N |
|
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HuLPr15359 |
ACETYLATION |
1052 |
K |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr15359 |
ACETYLATION |
1064 |
K |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr15359 |
ACETYLATION |
1069 |
K |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr15359 |
PHOSPHORYLATION |
283 |
S |
PhosphoSitePlus |
LTP |
yes |
|
|
|
HuLPr15359 |
PHOSPHORYLATION |
297 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr15359 |
PHOSPHORYLATION |
202 |
S |
PhosphoSitePlus |
LTP |
N |
|
