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Gene, Transcriptome, Protein, Pathway or Disease. 

Protein basic information

LiverAtlas Protein ID

HuLPr15425

Uniprot ID

CHIT1_HUMAN

Uniprot Acc

Q13231;Q0VGG5;Q0VGG6;Q3ZAR1;Q6ISC2;Q9H3V8;Q9UDJ8;

Protein name

Chitotriosidase-1

Comment

FUNCTION:Degrades chitin, chitotriose and chitobiose. May participate in the defense against nematodes and other pathogens. Isoform 3 has no enzymatic activity.||CATALYTIC ACTIVITY:Random hydrolysis of N-acetyl-beta-D- glucosaminide (1->4)-beta-linkages in chitin and chitodextrins.||SUBUNIT:Monomer.||SUBCELLULAR LOCATION:Secreted. Lysosome. Note=A small proportion is lysosomal.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q13231-1; Sequence=Displayed; Name=2; IsoId=Q13231-2; Sequence=VSP 008631, VSP 008632; Name=3; IsoId=Q13231-3; Sequence=VSP 008633; Note=Duplication of 24 bp in exon 10 leads to the use of a cryptic splice site. The normal splice site is still present but not used;||TISSUE SPECIFICITY:Detected in spleen. Secreted by cultured macrophages.||POLYMORPHISM:A 24 bp duplication in exon 10 leads to the activation of an alternative splice site and the production of an inactive protein. About 6% of the population are deficient fo

Subcellular localization

Secreted.Lysosome.

Gene name

chitinase 1 (chitotriosidase)

Protein sequence

MVRSVAWAGFMVLLMIPWGSAAKLVCYFTNWAQYRQGEAR FLPKDLDPSLCTHLIYAFAGMTNHQLSTTEWNDETLYQE FNGLKKMNPKLKTLLAIGGWNFGTQKFTDMVATANNRQT FVNSAIRFLRKYSFDGLDLDWEYPGSQGSPAVDKERFTT LVQDLANAFQQEAQTSGKERLLLSAAVPAGQTYVDAGYE VDKIAQNLDFVNLMAYDFHGSWEKVTGHNSPLYKRQEES GAAASLNVDAAVQQWLQKGTPASKLILGMPTYGRSFTLA SSSDTRVGAPATGSGTPGPFTKEGGMLAYYEVCSWKGAT KQRIQDQKVPYIFRDNQWVGFDDVESFKTKVSYLKQKGL GGAMVWALDLDDFAGFSCNQGRYPLIQTLRQELSLPYLP SGTPELEVPKPGQPSEPEHGPSPGQDTFCQGKADGLYPN PRERSSFYSCAAGRLFQQSCPTGLVFSNSCKCCTWN

Database cross reference

RefSeq Protein accession:NP_003456
RefSeq Protein gi:4502809

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Human Liver Organelles;

Ontology annotation

GO-C

GO:0005615;C:extracellular space;IDA:UniProtKB. GO:0005764;C:lysosome;IEA:UniProtKB-SubCell.

GO-F

GO:0043169;F:cation binding;IEA:InterPro. GO:0008061;F:chitin binding;TAS:UniProtKB. GO:0008843;F:endochitinase activity;IDA:UniProtKB.

GO-P

GO:0006032;P:chitin catabolic process;IDA:UniProtKB. GO:0006955;P:immune response;NAS:UniProtKB. GO:0009617;P:response to bacterium;TAS:ProtInc.

Pathway

Pathway name

Amino_Sugar_Metabolism