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Protein basic information

LiverAtlas Protein ID

HuLPr15446

Uniprot ID

CHPT1_HUMAN

Uniprot Acc

Q8WUD6;B3KQM2;Q7Z7H0;Q7Z7H1;Q7Z7H2;Q8IWQ4;Q8IWQ5;Q8WYI4;Q9NRQ6;Q9NRQ7;Q9Y6M6;

Protein name

Cholinephosphotransferase 1

Comment

FUNCTION:Catalyzes phosphatidylcholine biosynthesis from CDP- choline. It thereby plays a central role in the formation and maintenance of vesicular membranes.||CATALYTIC ACTIVITY:CDP-choline + 1,2-diacylglycerol = CMP + a phosphatidylcholine.||COFACTOR:Magnesium or manganese.||PATHWAY:Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine:step 2/2.||SUBCELLULAR LOCATION:Golgi apparatus membrane; Multi-pass membrane protein.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Alpha; IsoId=Q8WUD6-1; Sequence=Displayed; Name=2; Synonyms=Beta; IsoId=Q8WUD6-2; Sequence=VSP 025989, VSP 025990;||TISSUE SPECIFICITY:Highly expressed in testis, colon, small intestine, heart, prostate and spleen. Also detected in kidney, skeletal muscle, pancreas, leukocytes, ovary and thymus. Weakly expressed in the brain, placenta and lung. Overexpressed in cancerous breast epithelial cell lines.||SIMILARITY:Belongs to the CDP-alc

Subcellular localization

Golgi apparatus membrane;Multi-pass membrane protein.

Gene name

choline phosphotransferase 1

Protein sequence

MAAGAGAGSAPRWLRALSEPLSAAQLRRLEEHRYSAAGVS LLEPPLQLYWTWLLQWIPLWMAPNSITLLGLAVNVVTTL VLISYCPTATEEAPYWTYLLCALGLFIYQSLDAIDGKQA RRTNSCSPLGELFDHGCDSLSTVFMAVGASIAARLGTYP DWFFFCSFIGMFVFYCAHWQTYVSGMLRFGKVDVTEIQI ALVIVFVLSAFGGATMWDYTIPILEIKLKILPVLGFLGG VIFSCSNYFHVILHGGVGKNGSTIAGTSVLSPGLHIGLI IILAIMIYKKSATDVFEKHPCLYILMFGCVFAKVSQKLV VAHMTKSELYLQDTVFLGPGLLFLDQYFNNFIDEYVVLW MAMVISSFDMVIYFSALCLQISRHLHLNIFKTACHQAPE QVQVLSSKSHQNNMD

Database cross reference

RefSeq Protein accession:NP_064629
RefSeq Protein gi:50726996

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Liver Organelles;

Ontology annotation

GO-C

GO:0000139;C:Golgi membrane;IEA:UniProtKB-SubCell. GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. GO:0005792;C:microsome;NAS:UniProtKB.

GO-F

GO:0019992;F:diacylglycerol binding;NAS:UniProtKB. GO:0004142;F:diacylglycerol cholinephosphotransferase activity;IDA:UniProtKB. GO:0046872;F:metal ion binding;IEA:UniProtKB-KW.

GO-P

GO:0006663;P:platelet activating factor biosynthetic process;IDA:UniProtKB. GO:0001558;P:regulation of cell growth;NAS:UniProtKB.

Pathway

Pathway name

Phospholipid_Biosynthesis