HuLPr15449

Uniprot ID

CHRD1_HUMAN

Uniprot Acc

Q9UHD1;B2R6P8;Q6IN49;Q8WVL9;Q9H3D6;

Protein name

Cysteine and histidine-rich domain-containing protein 1

Comment

FUNCTION:Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2. Proposed to act as co-chaperone for HSP90. May play a role in the regulation of NOD1 via a HSP90 chaperone complex. In vitro, has intrinsic chaperone activity. This function may be achieved by inhibiting association of ROCK2 with NPM1. Involved in stress response. Prevents tumorigenesis.||SUBUNIT:Interacts with HSP90AA1, ROCK1 and ROCK2. Interacts with HSP90AB1 and PPP5C (By similarity).||INTERACTION:Self; NbExp=1; IntAct=EBI-2550959, EBI-2550959; P07900:HSP90AA1; NbExp=2; IntAct=EBI-2550959, EBI-296047;||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9UHD1-1; Sequence=Displayed; Name=2; IsoId=Q9UHD1-2; Sequence=VSP 031150; Note=No experimental confirmation available;||TISSUE SPECIFICITY:Underexpressed in many breast and lung cancers.||SIMILARITY:Contains 2 CHORD domains.||SIMILARITY:Contains 1 CS domain.||SEQUENCE CAUTION:Sequence=AAH17789.1; Type=Er

Gene name

cysteine and histidine-rich domain (CHORD) containing 1

Protein sequence

MALLCYNRGCGQRFDPETNSDDACTYHPGVPVFHDALKGW SCCKRRTTDFSDFLSIVGCTKGRHNSEKPPEPVKPEVKT TEKKELCELKPKFQEHIIQAPKPVEAIKRPSPDEPMTNL ELKISASLKQALDKLKLSSGNEENKKEEDNDEIKIGTSC KNGGCSKTYQGLESLEEVCVYHSGVPIFHEGMKYWSCCR RKTSDFNTFLAQEGCTKGKHMWTKKDAGKKVVPCRHDWH QTGGEVTISVYAKNSLPELSRVEANSTLLNVHIVFEGEK EFDQNVKLWGVIDVKRSYVTMTATKIEITMRKAEPMQWA SLELPAAKKQEKQKDATTD

Database cross reference

RefSeq Protein accession:NP_001137545
RefSeq Protein gi:221316570

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Liver Organelles;

GO-F

GO:0051879;F:Hsp90 protein binding;IPI:UniProtKB. GO:0042802;F:identical protein binding;IPI:IntAct.

GO-P

GO:0061077;P:chaperone-mediated protein folding;ISS:UniProtKB. GO:0080134;P:regulation of response to stress;ISS:UniProtKB. GO:0006950;P:response to stress;IEA:UniProtKB-KW.

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr15449

PHOSPHORYLATION

199

T

PhosphoSitePlus

480132

LTP

HTP

N

HuLPr15449

ACETYLATION

198

K

PhosphoSitePlus

14320262

LTP

N

HuLPr15449

ACETYLATION

220

K

PhosphoSitePlus

14320265

HTP

N

HuLPr15449

PHOSPHORYLATION

51

S

PhosphoSitePlus

3202443

LTP

N

HuLPr15449

PHOSPHORYLATION

47

T

PhosphoSitePlus

3202446

LTP

N

HuLPr15449

PHOSPHORYLATION

292

Y

PhosphoSitePlus

473442

LTP

N

HuLPr15449

PHOSPHORYLATION

200

S

PhosphoSitePlus

4774919

LTP

N

HuLPr15449

PHOSPHORYLATION

26

Y

PhosphoSitePlus

15561221

LTP

N

HuLPr15449

PHOSPHORYLATION

178

Y

PhosphoSitePlus

480735

LTP

HTP

N