Protein basic information
| LiverAtlas Protein ID |
HuLPr15457 |
|
Uniprot ID |
|
|
Uniprot Acc |
Q8NCG5;Q8IV46;Q9Y5R3; |
|
Protein name |
Carbohydrate sulfotransferase 4 |
|
Comment |
FUNCTION:Catalyzes the transfer of sulfate to position 6 of non- reducing N-acetylglucosamine (GlcNAc) residues within mucin- associated glycans that ultimately serve as L-selectin ligands. L- selectin ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. Participates in biosynthesis of L-selectin ligand sialyl 6-sulfo Lewis X on L-selectin counter receptors CD43, GlyCAM-1 and MAdCAM- 1. Also involved in biosynthesis of L-selectin ligand recognized by MECA-79 antibody. Plays a central role in lymphocyte trafficking during chronic inflammation. Has a catalytic preference for core 2-branched mucin-type O-glycans. Can use GlcNAcbeta1-6[Galbeta1-3]GalNAc-pNP (core 2), GlcNAcbeta1-6ManOMe and GlcNAcbeta1-2Man oligosaccharide structures as acceptors. Has also activity toward core 3 of GlcNAcbeta1-3GalNAc-pNP. Its substrate specificity may be influenced by its subcellular location.||SUBUNIT:Monomer.||SUBCELLULAR LOCATION:Go |
|
Subcellular localization |
Golgi apparatus membrane;Single-pass type II membrane protein. |
|
Gene name |
|
|
Protein sequence
|
MLLPKKMKLLLFLVSQMAILALFFHMYSHNISSLSMKAQP ERMHVLVLSSWRSGSSFVGQLFGQHPDVFYLMEPAWHVW MTFKQSTAWMLHMAVRDLIRAVFLCDMSVFDAYMEPGPR RQSSLFQWENSRALCSAPACDIIPQDEIIPRAHCRLLCS QQPFEVVEKACRSYSHVVLKEVRFFNLQSLYPLLKDPSL NLHIVHLVRDPRAVFRSRERTKGDLMIDSRIVMGQHEQK LKKEDQPYYVMQVICQSQLEIYKTIQSLPKALQERYLLV RYEDLARAPVAQTSRMYEFVGLEFLPHLQTWVHNITRGK GMGDHAFHTNARDALNVSQAWRWSLPYEKVSRLQKACGD AMNLLGYRHVRSEQEQRNLLLDLLSTWTVPEQIH |
|
Database cross reference |
RefSeq Protein accession:NP_001159867
|
Liver relevance
|
HLPP validation |
Yes/No |
Yes |
|
Project name |
Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. GO:0031228;C:intrinsic to Golgi membrane;NAS:UniProtKB. GO:0005802;C:trans-Golgi network;IDA:UniProtKB. |
|
GO-F |
GO:0001517;F:N-acetylglucosamine 6-O-sulfotransferase activity;IDA:UniProtKB. |
|
GO-P |
GO:0007267;P:cell-cell signaling;TAS:ProtInc. GO:0006955;P:immune response;TAS:ProtInc. GO:0006954;P:inflammatory response;IEA:UniProtKB-KW. GO:0006044;P:N-acetylglucosamine metabolic process;IDA:UniProtKB. GO:0006477;P:protein sulfation;TAS:ProtInc. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr15457 |
PHOSPHORYLATION |
359 |
Y |
PhosphoSitePlus |
LTP |
N |
 
|
