Protein basic information
| LiverAtlas Protein ID |
HuLPr15460 |
|
Uniprot ID |
|
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Uniprot Acc |
Q9NS84;O75667; |
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Protein name |
Carbohydrate sulfotransferase 7 |
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Comment |
FUNCTION:Catalyzes the transfer of sulfate to position 6 of non- reducing N-acetylglucosamine (GlcNAc) residues. Preferentially acts on mannose-linked GlcNAc. Also able to catalyze the transfer of sulfate to position 6 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Also acts on core 2 mucin-type oligosaccharide and N-acetyllactosamine oligomer with a lower efficiency. Has weak or no activity toward keratan sulfate and oligosaccharides containing the Galbeta1-4GlcNAc. Catalyzes 6-O- sulfation of beta-benzyl GlcNAc but not alpha- or beta-benzyl GalNAc.||CATALYTIC ACTIVITY:3'-phosphoadenylyl sulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate.||SUBCELLULAR LOCATION:Golgi apparatus membrane; Single-pass type II membrane protein (By similarity).||TISSUE SPECIFICITY:Widely expressed. Highly expressed in heart, spleen, liver and ovary. Expressed at lower level in brain, placenta, thyroid, spinal cord and peripheral blood leukocytes. Not expressed in ad |
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Subcellular localization |
Golgi apparatus membrane;Single-pass type II membrane protein(By similarity). |
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Gene name |
|
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Protein sequence
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MKGRRRRRREYCKFALLLVLYTLVLLLVPSVLDGGRDGDK GAEHCPGLQRSLGVWSLEAAAAGEREQGAEARAAEEGGA NQSPRFPSNLSGAVGEAVSREKQHIYVHATWRTGSSFLG ELFNQHPDVFYLYEPMWHLWQALYPGDAESLQGALRDML RSLFRCDFSVLRLYAPPGDPAARAPDTANLTTAALFRWR TNKVICSPPLCPGAPRARAEVGLVEDTACERSCPPVAIR ALEAECRKYPVVVIKDVRLLDLGVLVPLLRDPGLNLKVV QLFRDPRAVHNSRLKSRQGLLRESIQVLRTRQRGDRFHR VLLAHGVGARPGGQSRALPAAPRADFFLTGALEVICEAW LRDLLFARGAPAWLRRRYLRLRYEDLVRQPRAQLRRLLR FSGLRALAALDAFALNMTRGAAYGADRPFHLSARDAREA VHAWRERLSREQVRQVEAACAPAMRLLAYPRSGEEGDAE QPREGETPLEMDADGAT |
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Database cross reference |
RefSeq Protein accession:NP_063939
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Liver relevance
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HLPP validation |
Yes/No |
Yes |
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Project name |
Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0000139;C:Golgi membrane;IEA:UniProtKB-SubCell. GO:0016021;C:integral to membrane;NAS:UniProtKB. |
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GO-F |
GO:0008459;F:chondroitin 6-sulfotransferase activity;IDA:UniProtKB. GO:0001517;F:N-acetylglucosamine 6-O-sulfotransferase activity;IDA:UniProtKB. |
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GO-P |
GO:0030206;P:chondroitin sulfate biosynthetic process;IDA:UniProtKB. GO:0006044;P:N-acetylglucosamine metabolic process;IDA:UniProtKB. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr15460 |
PHOSPHORYLATION |
459 |
Y |
PhosphoSitePlus |
LTP |
N |
 
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