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Protein basic information

LiverAtlas Protein ID

HuLPr15464

Uniprot ID

CHSTB_HUMAN

Uniprot Acc

Q9NPF2;A8K4F8;Q9NXY6;Q9NY36;

Protein name

Carbohydrate sulfotransferase 11

Comment

FUNCTION:Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Can also sulfate Gal residues in desulfated dermatan sulfate. Preferentially sulfates in GlcA->GalNAc unit than in IdoA->GalNAc unit. Does not form 4, 6- di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor.||CATALYTIC ACTIVITY:3'-phosphoadenylyl sulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate.||BIOPHYSICOCHEMICAL PROPERTIES:Kinetic parameters: KM=0.5 uM for PAPS; KM=2.1 mM for chondroitin;||SUBCELLULAR LOCATION:Golgi apparatus membrane; Single-pass type II membrane protein (By similarity).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NPF2-1; Sequence=Displayed; Name=2; Synonyms=C4S-1A; IsoId=Q9NPF2-2; Sequence=VSP 01299

Subcellular localization

Golgi apparatus membrane;Single-pass type II membrane protein(By similarity).

Gene name

carbohydrate (chondroitin 4) sulfotransferase 11

Protein sequence

MKPALLEVMRMNRICRMVLATCLGSFILVIFYFQSMLHPV MRRNPFGVDICCRKGSRSPLQELYNPIQLELSNTAVLHQ MRRDQVTDTCRANSATSRKRRVLTPNDLKHLVVDEDHEL IYCYVPKVACTNWKRLMMVLTGRGKYSDPMEIPANEAHV SANLKTLNQYSIPEINHRLKSYMKFLFVREPFERLVSAY RNKFTQKYNISFHKRYGTKIIKRQRKNATQEALRKGDDV KFEEFVAYLIDPHTQREEPFNEHWQTVYSLCHPCHIHYD LVGKYETLEEDSNYVLQLAGVGSYLKFPTYAKSTRTTDE MTTEFFQNISSEHQTQLYEVYKLDFLMFNYSVPSYLKLE

Database cross reference

RefSeq Protein accession:NP_001167453
RefSeq Protein gi:291219907

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;

Ontology annotation

GO-C

GO:0000139;C:Golgi membrane;IEA:UniProtKB-SubCell. GO:0016021;C:integral to membrane;NAS:UniProtKB.

GO-F

GO:0047756;F:chondroitin 4-sulfotransferase activity;IDA:UniProtKB. GO:0001537;F:N-acetylgalactosamine 4-O-sulfotransferase activity;IDA:UniProtKB.

GO-P

GO:0030206;P:chondroitin sulfate biosynthetic process;IDA:UniProtKB.

Pathway

Pathway name

TCR