HuLPr15691

Uniprot ID

CLC10_HUMAN

Uniprot Acc

Q8IUN9;A8K8J8;Q14538;Q6PIW3;

Protein name

C-type lectin domain family 10 member A

Comment

FUNCTION:Probable role in regulating adaptive and innate immune responses. Binds in a calcium-dependent manner to terminal galactose and N-acetylgalactosamine units, linked to serine or threonine. These sugar moieties are known as Tn-Ag and are expressed in a variety of carcinoma cells.||SUBCELLULAR LOCATION:Membrane; Single-pass type II membrane protein (Probable).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8IUN9-1; Sequence=Displayed; Name=2; IsoId=Q8IUN9-2; Sequence=VSP 012848, VSP 012849; Name=3; IsoId=Q8IUN9-3; Sequence=VSP 012848, VSP 012850, VSP 012851;||SIMILARITY:Contains 1 C-type lectin domain.||WEB RESOURCE:Name=Functional Glycomics Gateway - Glycan Binding; Note=MGL; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp hum Ctlect 217";

Subcellular localization

Membrane;Single-pass type II membrane protein(Probable).

Gene name

C-type lectin domain family 10, member A

Protein sequence

MTRTYENFQYLENKVKVQGFKNGPLPLQSLLQRLCSGPCH LLLSLGLGLLLLVIICVVGFQNSKFQRDLVTLRTDFSNF TSNTVAEIQALTSQGSSLEETIASLKAEVEGFKQERQAG VSELQEHTTQKAHLGHCPHCPSVCVPVHSEMLLRVQQLV QDLKKLTCQVATLNNNASTEGTCCPVNWVEHQDSCYWFS HSGMSWAEAEKYCQLKNAHLVVINSREEQNFVQKYLGSA YTWMGLSDPEGAWKWVDGTDYATGFQNWKPGQPDDWQGH GLGGGEDCAHFHPDGRWNDDVCQRPYHWVCEAGLGQTSQESH

Database cross reference

RefSeq Protein accession:NP_006335
RefSeq Protein gi:53832016

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;

GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. GO:0005886;C:plasma membrane;TAS:ProtInc.

GO-F

GO:0005529;F:sugar binding;TAS:ProtInc.

GO-P

GO:0006897;P:endocytosis;IEA:UniProtKB-KW. GO:0045087;P:innate immune response;IEA:UniProtKB-KW.