Choose one of the five choices you want to search:

Gene, Transcriptome, Protein, Pathway or Disease. 

Protein basic information

LiverAtlas Protein ID

HuLPr15697

Uniprot ID

CLC2D_HUMAN

Uniprot Acc

Q9UHP7;D6CI39;D6CI40;D6CI41;Q6YID5;Q8WUP7;Q9HD37;Q9HD38;

Protein name

C-type lectin domain family 2 member D

Comment

FUNCTION:Receptor for KLRB1 that protects target cells against natural killer cell-mediated lysis. Inhibits osteoclast formation. Inhibits bone resorption. Modulates the release of interferon- gamma. Binds high molecular weight sulfated glycosaminoglycans.||SUBUNIT:Homodimer or heterodimer; disulfide-linked.||SUBCELLULAR LOCATION:Cell membrane; Single-pass type II membrane protein. Cell surface.||SUBCELLULAR LOCATION:Isoform 2:Endoplasmic reticulum.||SUBCELLULAR LOCATION:Isoform 4:Endoplasmic reticulum.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=6; Name=1; IsoId=Q9UHP7-1; Sequence=Displayed; Name=3; IsoId=Q9UHP7-2; Sequence=VSP 039682; Name=2; IsoId=Q9UHP7-3; Sequence=VSP 039683; Name=4; IsoId=Q9UHP7-5; Sequence=VSP 039678; Name=5; IsoId=Q9UHP7-6; Sequence=VSP 039676; Name=6; IsoId=Q9UHP7-7; Sequence=VSP 039676, VSP 039680, VSP 039681;||TISSUE SPECIFICITY:Detected in peripheral blood leukocytes, osteoblasts, lymph node, thymus and spleen. Isoform 1, is

Subcellular localization

Cell membrane;Single-pass type II membrane protein.Cell surface.

Gene name

C-type lectin domain family 2, member D

Protein sequence

MHDSNNVEKDITPSELPANPGCLHSKEHSIKATLIWRLFF LIMFLTIIVCGMVAALSAIRANCHQEPSVCLQAACPESW IGFQRKCFYFSDDTKNWTSSQRFCDSQDADLAQVESFQE LNFLLRYKGPSDHWIGLSREQGQPWKWINGTEWTRQFPI LGAGECAYLNDKGASSARHYTERKWICSKSDIHV

Database cross reference

RefSeq Protein accession:NP_001004419
RefSeq Protein gi:52426782

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Liver Organelles;

Ontology annotation

GO-C

GO:0009986;C:cell surface;IDA:UniProtKB. GO:0005783;C:endoplasmic reticulum;IDA:UniProtKB. GO:0005887;C:integral to plasma membrane;TAS:ProtInc. GO:0005624;C:membrane fraction;TAS:ProtInc.

GO-F

GO:0005529;F:sugar binding;IEA:UniProtKB-KW. GO:0004888;F:transmembrane receptor activity;TAS:ProtInc.

GO-P

GO:0007166;P:cell surface receptor linked signaling pathway;TAS:ProtInc.