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Protein basic information

LiverAtlas Protein ID

HuLPr15716

Uniprot ID

CLCL1_HUMAN

Uniprot Acc

Q8IZS7;

Protein name

C-type lectin-like domain family 1

Comment

FUNCTION:May function in mediating immune cell-cell interactions. May act as a T-cell costimulatory molecule, enhancing anti-CD3- induced proliferation. May play a role in the interaction of dendritic cells with T-cells and the cells of the adaptive immune response.||SUBCELLULAR LOCATION:Cell membrane; Single-pass type II membrane protein.||TISSUE SPECIFICITY:Expressed in spleen, lymph node, and tonsil. Lower expression in peripheral blood, bone marrow, and colon. No expression detected in thymus. Highly expressed in dendritic and B-cells.||SIMILARITY:Contains 1 C-type lectin domain.

Subcellular localization

Cell membrane;Single-pass type II membrane protein.

Gene name

C-type lectin-like 1

Protein sequence

MVSNFFHVIQVFEKSATLISKTEHIGFVIYSWRKSTTHLG SRRKFAISIYLSEVSLQKYDCPFSGTSFVVFSLFLICAM AGDVVYADIKTVRTSPLELAFPLQRSVSFNFSTVHKSCP AKDWKVHKGKCYWIAETKKSWNKSQNDCAINNSYLMVIQ DITAMVRFNI

Database cross reference

RefSeq Protein accession:NP_742001
RefSeq Protein gi:25188187

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Liver Organelles;

Ontology annotation

GO-C

GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. GO:0005886;C:plasma membrane;IEA:UniProtKB-SubCell.

GO-F

GO:0005529;F:sugar binding;IEA:UniProtKB-KW.