HuLPr15745

Uniprot ID

CLH1_HUMAN

Uniprot Acc

Q00610;D3DU00;Q6N0A0;Q86TF2;

Protein name

Clathrin heavy chain 1

Comment

FUNCTION:Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network.||SUBUNIT:Clathrin triskelions, composed of 3 heavy chains and 3 light chains, are the basic subunits of the clathrin coat. In the presence of light chains, hub assembly is influenced by both the pH and the concentration of calcium. Interacts with HIP1. Interacts with DENND1A, DENND1B and DENND1C (By similarity). May interact with OCRL (By similarity).||INTERACTION:Q14164:IKBKE; NbExp=1; IntAct=EBI-354967, EBI-307369; P23508:MCC; NbExp=1; IntAct=EBI-354967, EBI-307531; Q92597:NDRG1; NbExp=1; IntAct=EBI-354967, EBI-716486; Q9CQJ7:Pttg1 (xeno); NbExp=1; IntAct=EBI-354967, EBI-2551713; P19532:TFE3; NbExp=1; IntAct=EBI-354967, EBI-1048957; Q17R13:TNK2 (xeno); NbExp=1; IntAct=EBI-354967, EBI-457220;||SUBCELLULAR LOCATION:Cytoplasmic vesicle membrane; Peripheral membrane protein

Subcellular localization

Cytoplasmic vesicle membrane;Peripheral membrane protein;Cytoplasmic side.Membrane, coated pit;Peripheral membrane protein;Cytoplasmic side.Melanosome.

Gene name

clathrin, heavy chain (Hc)

Related liver disease name

Hepatocellular carcinoma

Protein sequence

MAQILPIRFQEHLQLQNLGINPANIGFSTLTMESDKFICI REKVGEQAQVVIIDMNDPSNPIRRPISADSAIMNPASKV IALKAGKTLQIFNIEMKSKMKAHTMTDDVTFWKWISLNT VALVTDNAVYHWSMEGESQPVKMFDRHSSLAGCQIINYR TDAKQKWLLLTGISAQQNRVVGAMQLYSVDRKVSQPIEG HAASFAQFKMEGNAEESTLFCFAVRGQAGGKLHIIEVGT PPTGNQPFPKKAVDVFFPPEAQNDFPVAMQISEKHDVVF LITKYGYIHLYDLETGTCIYMNRISGETIFVTAPHEATA GIIGVNRKGQVLSVCVEEENIIPYITNVLQNPDLALRMA VRNNLAGAEELFARKFNALFAQGNYSEAAKVAANAPKGI LRTPDTIRRFQSVPAQPGQTSPLLQYFGILLDQGQLNKY ESLELCRPVLQQGRKQLLEKWLKEDKLECSEELGDLVKS VDPTLALSVYLRANVPNKVIQCFAETGQVQKIVLYAKKV GYTPDWIFLLRNVMRISPDQGQQFAQMLVQDEEPLADIT QIVDVFMEYNLIQQCTAFLLDALKNNRPSEGPLQTRLLE MNLMHAPQVADAILGNQMFTHYDRAHIAQLCEKAGLLQR ALEHFTDLYDIKRAVVHTHLLNPEWLVNYFGSLSVEDSL ECLRAMLSANIRQNLQICVQVASKYHEQLSTQSLIELFE SFKSFEGLFYFLGSIVNFSQDPDVHFKYIQAACKTGQIK EVERICRESNCYDPERVKNFLKEAKLTDQLPLIIVCDRF DFVHDLVLYLYRNNLQKYIEIYVQKVNPSRLPVVIGGLL DVDCSEDVIKNLILVVRGQFSTDELVAEVEKRNRLKLLL PWLEARIHEGCEEPATHNALAKIYIDSNNNPERFLRENP YYDSRVVGKYCEKRDPHLACVAYERGQCDLELINVCNEN SLFKSLSRYLVRRKDPELWGSVLLESNPYRRPLIDQVVQ TALSETQDPEEVSVTVKAFMTADL

Database cross reference

RefSeq Protein accession:NP_004850
RefSeq Protein gi:4758012

HCC significant Proteins

Yes/No

Yes

Quality score

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Fetal Liver;Human Liver Organelles;

GO:0030132;C:clathrin coat of coated pit;IEA:InterPro. GO:0030130;C:clathrin coat of trans-Golgi network vesicle;IEA:InterPro. GO:0005829;C:cytosol;TAS:Reactome. GO:0042470;C:melanosome;IEA:UniProtKB-SubCell. GO:0005819;C:spindle;IDA:UniProtKB.

GO-F

GO:0005515;F:protein binding;IPI:UniProtKB. GO:0005198;F:structural molecule activity;NAS:UniProtKB.

GO-P