HuLPr15746

Uniprot ID

CLH2_HUMAN

Uniprot Acc

P53675;B7Z7U5;Q14017;Q15808;Q15809;

Protein name

Clathrin heavy chain 2

Comment

FUNCTION:Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network (By similarity).||SUBUNIT:Clathrin triskelions, composed of 3 heavy chains and 3 light chains, are the basic subunits of the clathrin coat. In the presence of light chains, hub assembly is influenced by both the pH and the concentration of calcium (By similarity). May interact with OCRL (By similarity).||SUBCELLULAR LOCATION:Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side (By similarity). Note=Cytoplasmic face of coated pits and vesicles (By similarity).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Long, Brain; IsoId=P53675-1; Sequence=Displayed; Name=2; Synonyms=Short, Muscle; IsoId=P53675-2; Sequence=VSP 001100;||TIS

Subcellular localization

Cytoplasmic vesicle membrane;Peripheral membrane protein;Cytoplasmic side(By similarity).Membrane, coated pit;Peripheral membrane protein;Cytoplasmic side(By similarity).

Gene name

clathrin, heavy chain-like 1

Related liver disease name

Hepatocellular carcinoma

Protein sequence

MAQILPVRFQEHFQLQNLGINPANIGFSTLTMESDKFICI REKVGEQAQVTIIDMSDPMAPIRRPISAESAIMNPASKV IALKAGKTLQIFNIEMKSKMKAHTMAEEVIFWKWVSVNT VALVTETAVYHWSMEGDSQPMKMFDRHTSLVGCQVIHYR TDEYQKWLLLVGISAQQNRVVGAMQLYSVDRKVSQPIEG HAAAFAEFKMEGNAKPATLFCFAVRNPTGGKLHIIEVGQ PAAGNQPFVKKAVDVFFPPEAQNDFPVAMQIGAKHGVIY LITKYGYLHLYDLESGVCICMNRISADTIFVTAPHKPTS GIIGVNKKGQVLSVCVEEDNIVNYATNVLQNPDLGLRLA VRSNLAGAEKLFVRKFNTLFAQGSYAEAAKVAASAPKGI LRTRETVQKFQSIPAQSGQASPLLQYFGILLDQGQLNKL ESLELCHLVLQQGRKQLLEKWLKEDKLECSEELGDLVKT TDPMLALSVYLRANVPSKVIQCFAETGQFQKIVLYAKKV GYTPDWIFLLRGVMKISPEQGLQFSRMLVQDEEPLANIS QIVDIFMENSLIQQCTSFLLDALKNNRPAEGLLQTWLLE MNLVHAPQVADAILGNKMFTHYDRAHIAQLCEKAGLLQQ ALEHYTDLYDIKRAVVHTHLLNPEWLVNFFGSLSVEDSV ECLHAMLSANIRQNLQLCVQVASKYHEQLGTQALVELFE SFKSYKGLFYFLGSIVNFSQDPDVHLKYIQAACKTGQIK EVERICRESSCYNPERVKNFLKEAKLTDQLPLIIVCDRF GFVHDLVLYLYRNNLQRYIEIYVQKVNPSRTPAVIGGLL DVDCSEEVIKHLIMAVRGQFSTDELVAEVEKRNRLKLLL PWLESQIQEGCEEPATHNALAKIYIDSNNSPECFLRENA YYDSSVVGRYCEKRDPHLACVAYERGQCDLELIKVCNEN SLFKSEARYLVCRKDPELWAHVLEETNPSRRQLIDQVVQ TALSETRDPEEISVTVKAFMTADL

Database cross reference

RefSeq Protein accession:NP_001826
RefSeq Protein gi:242247001

HCC significant Proteins

Yes/No

Yes

Quality score

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Liver Organelles;

GO:0030132;C:clathrin coat of coated pit;IEA:InterPro. GO:0030130;C:clathrin coat of trans-Golgi network vesicle;IEA:InterPro. GO:0005819;C:spindle;IDA:UniProtKB. GO:0005802;C:trans-Golgi network;IDA:UniProtKB.

GO-F

GO:0005515;F:protein binding;IPI:UniProtKB. GO:0004871;F:signal transducer activity;TAS:ProtInc. GO:0005198;F:structural molecule activity;IEA:InterPro.

GO-P