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Protein basic information

LiverAtlas Protein ID

HuLPr15763

Uniprot ID

CLM7_HUMAN

Uniprot Acc

A8K4G0;Q1EG73;Q8IX40;Q8N6D1;

Protein name

CMRF35-like molecule 7

Comment

FUNCTION:Acts as an activating immune receptor through its interaction with ITAM-bearing adapter TYROBP, and also independently by recruitement of GRB2.||SUBUNIT:Interacts with TYROBP, which enhances cell surface expression and activation properties. Interacts with GRB2 in the presence of FYN.||SUBCELLULAR LOCATION:Cell membrane; Single-pass type I membrane protein (By similarity).||TISSUE SPECIFICITY:Expressed exclusively in myeloid lineages.||PTM:Phosphorylation on Tyr-188 by FYN is required for interaction with GRB2.||SIMILARITY:Belongs to the CD300 family.||SIMILARITY:Contains 1 Ig-like V-type (immunoglobulin-like) domain.||SEQUENCE CAUTION:Sequence=AAH28091.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAF83614.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=EAW89170.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

Subcellular localization

Cell membrane;Single-pass type I membrane protein(By similarity).

Gene name

CD300 molecule-like family member b

Protein sequence

MWLPPALLLLSLSGCFSIQGPESVRAPEQGSLTVQCHYKQ GWETYIKWWCRGVRWDTCKILIETRGSEQGEKSDRVSIK DNQKDRTFTVTMEGLRRDDADVYWCGIERRGPDLGTQVK VIVDPEGAASTTASSPTNSNMAVFIGSHKRNHYMLLVFV KVPILLILVTAILWLKGSQRVPEEPGEQPIYMNFSEPLT KDMAT

Database cross reference

RefSeq Protein accession:NP_777552
RefSeq Protein gi:154759271

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;

Ontology annotation

GO-C

GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. GO:0005886;C:plasma membrane;IEA:UniProtKB-SubCell.

GO-F

GO:0004872;F:receptor activity;IEA:UniProtKB-KW.