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Protein basic information

LiverAtlas Protein ID

HuLPr15790

Uniprot ID

CLYBL_HUMAN

Uniprot Acc

Q8N0X4;Q5W0F7;Q8TDH8;

Protein name

Citrate lyase subunit beta-like protein, mitochondrial

Comment

COFACTOR:Binds 1 magnesium ion per subunit (By similarity).||SUBCELLULAR LOCATION:Mitochondrion (Potential).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8N0X4-1; Sequence=Displayed; Name=2; IsoId=Q8N0X4-2; Sequence=VSP 034643; Note=No experimental confirmation available;||SIMILARITY:Belongs to the HpcH/HpaI aldolase family. Citrate lyase beta subunit-like subfamily.||CAUTION:This organism lacks the other subunits that are necessary for ATP-independent citrate lyase activity. Even though this protein has clear similarity to citrate lyase beta subunit, it is expected to have a somewhat different enzyme activity.

Subcellular localization

Mitochondrion(Potential).

Gene name

citrate lyase beta like

Protein sequence

MALRLLRRAARGAAAAALLRLKASLAADIPRLGYSSSSHH KYIPRRAVLYVPGNDEKKIKKIPSLNVDCAVLDCEDGVA ANKKNEARLRIVKTLEDIDLGPTEKCVRVNSVSSGLAEE DLETLLQSRVLPSSLMLPKVESPEEIQWFADKFSFHLKG RKLEQPMNLIPFVETAMGLLNFKAVCEETLKVGPQVGLF LDAVVFGGEDFRASIGATSSKETLDILYARQKIVVIAKA FGLQAIDLVYIDFRDGAGLLRQSREGAAMGFTGKQVIHP NQIAVVQEQFSPSPEKIKWAEELIAAFKEHQQLGKGAFT FQGSMIDMPLLKQAQNTVTLATSIKEK

Database cross reference

RefSeq Protein accession:NP_996531
RefSeq Protein gi:45545437

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Human Fetal Liver;Chinese Liver;French Liver;Human Liver Organelles;

Ontology annotation

GO-C

GO:0009346;C:citrate lyase complex;IEA:InterPro. GO:0005739;C:mitochondrion;IEA:UniProtKB-SubCell.

GO-F

GO:0008815;F:citrate (pro-3S)-lyase activity;IEA:InterPro. GO:0046872;F:metal ion binding;IEA:UniProtKB-KW.

GO-P

GO:0006725;P:cellular aromatic compound metabolic process;IEA:InterPro.