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Protein basic information

LiverAtlas Protein ID

HuLPr15811

Uniprot ID

CMPK2_HUMAN

Uniprot Acc

Q5EBM0;A2RUB0;A5D8T2;B7ZM18;Q6ZRU2;Q96AL8;

Protein name

UMP-CMP kinase 2, mitochondrial

Comment

FUNCTION:May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP; CMP and UMP are poor substrates. May be involved in mtDNA depletion caused by long term treatment with ddC or other pyrimidine analogs.||CATALYTIC ACTIVITY:ATP + (d)CMP = ADP + (d)CDP.||BIOPHYSICOCHEMICAL PROPERTIES:Kinetic parameters: KM=3.09 mM for CMP; KM=6.3 mM for UMP; KM=1.31 mM for dCMP; KM=0.1 mM for dUMP; Vmax=1.64 umol/min/mg enzyme towards CMP; Vmax=0.19 umol/min/mg enzyme towards UMP; Vmax=1.77 umol/min/mg enzyme towards dCMP; Vmax=0.48 umol/min/mg enzyme towards dUMP;||SUBCELLULAR LOCATION:Mitochondrion.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q5EBM0-1; Sequence=Displayed; Name=2; IsoId=Q5EBM0-2; Sequence=VSP 033238, VSP 033239; Note=No

Subcellular localization

Mitochondrion.

Gene name

cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial

Protein sequence

MAFARRLLRGPLSGPLLGRRGVCAGAMAPPRRFVLELPDC TLAHFALGADAPGDADAPDPRLAALLGPPERSYSLCVPV TPDAGCGARVRAARLHQRLLHQLRRGPFQRCQLLRLLCY CPGGQAGGAQQGFLLRDPLDDPDTRQALLELLGACQEAP RPHLGEFEADPRGQLWQRLWEVQDGRRLQVGCAQVVPVP EPPLHPVVPDLPSSVVFPDREAARAVLEECTSFIPEARA VLDLVDQCPKQIQKGKFQVVAIEGLDATGKTTVTQSVAD SLKAVLLKSPPSCIGQWRKIFDDEPTIIRRAFYSLGNYI VASEIAKESAKSPVIVDRYWHSTATYAIATEVSGGLQHL PPAHHPVYQWPEDLLKPDLILLLTVSPEERLQRLQGRGM EKTREEAELEANSVFRQKVEMSYQRMENPGCHVVDASPS REKVLQTVLSLIQNSFSEP

Database cross reference

RefSeq Protein accession:NP_997198
RefSeq Protein gi:117606370

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Human Liver Organelles;

Ontology annotation

GO-C

GO:0005739;C:mitochondrion;IDA:MGI.

GO-F

GO:0005524;F:ATP binding;IEA:UniProtKB-KW. GO:0004127;F:cytidylate kinase activity;IDA:MGI. GO:0004798;F:thymidylate kinase activity;IEA:InterPro. GO:0033862;F:UMP kinase activity;IDA:MGI.

GO-P

GO:0006233;P:dTDP biosynthetic process;IEA:InterPro.

Pathway

Pathway name

Pyrimidine_Metabolism