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Protein basic information

LiverAtlas Protein ID

HuLPr15857

Uniprot ID

CNDP1_HUMAN

Uniprot Acc

Q96KN2;Q14D40;Q17S05;Q2TBG0;Q6UWK2;Q9BT98;

Protein name

Beta-Ala-His dipeptidase

Comment

CATALYTIC ACTIVITY:Preferential hydrolysis of the beta-Ala-|-His dipeptide (carnosine), and also anserine, Xaa-|-His dipeptides and other dipeptides including homocarnosine.||COFACTOR:Binds 2 zinc ions per subunit (By similarity).||ENZYME REGULATION:Inhibited by the metal chelator 1,10-o- phenantrolin. The inhibitory concentration 50% (IC(50)) is 5 uM.||BIOPHYSICOCHEMICAL PROPERTIES:Kinetic parameters: KM=1.27 uM for carnosine (at 30 degrees Celsius and in the absence of cadmium ions); KM=11.00 uM for carnosine (at 30 degrees Celsius and in the presence of 200 uM cadmium ions); KM=0.20 uM for homocarnosine (at 30 degrees Celsius and in the absence of cadmium ions); KM=1.0 uM for homocarnosine (at 30 degrees Celsius and in the presence of 200 uM cadmium ions); Note=1 hour incubation in 50 mM Tris-HCl, pH 7.5; pH dependence: Optimum pH is 8.5;||SUBUNIT:Homodimer.||SUBCELLULAR LOCATION:Secreted.||TISSUE SPECIFICITY:Found in serum and adult nervous central system. Absent

Subcellular localization

Secreted.

Gene name

carnosine dipeptidase 1 (metallopeptidase M20 family)

Protein sequence

MDPKLGRMAASLLAVLLLLLERGMFSSPSPPPALLEKVFQ YIDLHQDEFVQTLKEWVAIESDSVQPVPRFRQELFRMMA VAADTLQRLGARVASVDMGPQQLPDGQSLPIPPIILAEL GSDPTKGTVCFYGHLDVQPADRGDGWLTDPYVLTEVDGK LYGRGATDNKGPVLAWINAVSAFRALEQDLPVNIKFIIE GMEEAGSVALEELVEKEKDRFFSGVDYIVISDNLWISQR KPAITYGTRGNSYFMVEVKCRDQDFHSGTFGGILHEPMA DLVALLGSLVDSSGHILVPGIYDEVVPLTEEEINTYKAI HLDLEEYRNSSRVEKFLFDTKEEILMHLWRYPSLSIHGI EGAFDEPGTKTVIPGRVIGKFSIRLVPHMNVSAVEKQVT RHLEDVFSKRNSSNKMVVSMTLGLHPWIANIDDTQYLAA KRAIRTVFGTEPDMIRDGSTIPIAKMFQEIVHKSVVLIP LGAVDDGEHSQNEKINRWNYIEGTKLFAAFFLEMAQLH

Database cross reference

RefSeq Protein accession:NP_116038
RefSeq Protein gi:21071039

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Human Liver Organelles;

Ontology annotation

GO-C

GO:0005576;C:extracellular region;IEA:UniProtKB-SubCell.

GO-F

GO:0004180;F:carboxypeptidase activity;IEA:UniProtKB-KW. GO:0016805;F:dipeptidase activity;IEA:InterPro. GO:0046872;F:metal ion binding;IEA:UniProtKB-KW. GO:0008237;F:metallopeptidase activity;IEA:UniProtKB-KW. GO:0034701;F:tripeptidase activity;IEA:In

GO-P

GO:0006508;P:proteolysis;IEA:InterPro.

Pathway

Pathway name

Beta-Alanine_Metabolism

Pathway name

Histidine_Metabolism

Pathway name

Homocarnosinosis