HuLPr15859

Uniprot ID

CNEP1_HUMAN

Uniprot Acc

O95476;D3DTN7;Q96GQ9;

Protein name

CTD nuclear envelope phosphatase 1

Comment

FUNCTION:Serine/threonine phosphatase which may be required for proper nuclear membrane morphology. Involved in LPIN1 dephosphorylation. May antagonize BMP signaling.||CATALYTIC ACTIVITY:A phosphoprotein + H(2)O = a protein + phosphate.||BIOPHYSICOCHEMICAL PROPERTIES:Kinetic parameters: KM=18 mM for p-nitrophenylphosphate; pH dependence: Optimum pH is 5.5;||SUBCELLULAR LOCATION:Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein.||SIMILARITY:Belongs to the dullard family.||SIMILARITY:Contains 1 FCP1 homology domain.

Subcellular localization

Endoplasmic reticulum membrane;Single-pass membrane protein.Nucleus membrane;Single-pass membrane protein.

Gene name

CTD nuclear envelope phosphatase 1

Protein sequence

MMRTQCLLGLRTFVAFAAKLWSFFIYLLRRQIRTVIQYQT VRYDILPLSPVSRNRLAQVKRKILVLDLDETLIHSHHDG VLRPTVRPGTPPDFILKVVIDKHPVRFFVHKRPHVDFFL EVVSQWYELVVFTASMEIYGSAVADKLDNSRSILKRRYY RQHCTLELGSYIKDLSVVHSDLSSIVILDNSPGAYRSHP DNAIPIKSWFSDPSDTALLNLLPMLDALRFTADVRSVLS RNLHQHRLW

Database cross reference

RefSeq Protein accession:NP_001137247
RefSeq Protein gi:219555649

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Liver Organelles;

GO:0005789;C:endoplasmic reticulum membrane;IDA:UniProtKB. GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. GO:0031965;C:nuclear membrane;IEA:UniProtKB-SubCell.

GO-F

GO:0004722;F:protein serine/threonine phosphatase activity;IMP:UniProtKB.

GO-P

GO:0006998;P:nuclear envelope organization;IDA:UniProtKB. GO:0006470;P:protein dephosphorylation;IDA:UniProtKB.

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr15859

PHOSPHORYLATION

49

S

Phospho-ELM

40893

HTP

N

TGF-