HuLPr15864

Uniprot ID

CNGB1_HUMAN

Uniprot Acc

Q14028;O43636;Q13059;Q14029;Q9UMG2;

Protein name

Cyclic nucleotide-gated cation channel beta-1

Comment

FUNCTION:Subunit of cyclic nucleotide-gated (CNG) channels, nonselective cation channels, which play important roles in both visual and olfactory signal transduction. When associated with CNGA1, it is involved in the regulation of ion flow into the rod photoreceptor outer segment (ROS), in response to light-induced alteration of the levels of intracellular cGMP.||FUNCTION:Isoform GARP2 is a high affinity rod photoreceptor phosphodiesterase (PDE6)-binding protein that modulates its catalytic properties:it is a regulator of spontaneous activation of rod PDE6, thereby serving to lower rod photoreceptor 'dark noise' and allowing these sensory cells to operate at the single photon detection limit.||SUBUNIT:Heterooligomeric complex with CNGA1.||SUBCELLULAR LOCATION:Membrane; Multi-pass membrane protein.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=3; Comment=There is no evidence for an ortholog to bovine GARP1 in the human genome; Name=RCNC2B; IsoId=Q14028-1; Sequen

Subcellular localization

Membrane;Multi-pass membrane protein.

Gene name

cyclic nucleotide gated channel beta 1

Protein sequence

MLGWVQRVLPQPPGTPRKTKMQEEEEVEPEPEMEAEVEPE PNPEEAETESESMPPEESFKEEEVAVADPSPQETKEAAL TSTISLRAQGAEISEMNSPSRRVLTWLMKGVEKVIPQPV HSITEDPAQILGHGSTGDTGCTDEPNEALEAQDTRPGLR LLLWLEQNLERVLPQPPKSSEVWRDEPAVATGAASDPAP PGRPQEMGPKLQARETPSLPTPIPLQPKEEPKEAPAPEP QPGSQAQTSSLPPTRDPARLVAWVLHRLEMALPQPVLHG KIGEQEPDSPGICDVQTISILPGGQVEPDLVLEEVEPPW EDAHQDVSTSPQGTEVVPAYEEENKAVEKMPRELSRIEE EKEDEEEEEEEEEEEEEEEVTEVLLDSCVVSQVGVGQSE EDGTRPQSTSDQKLWEEVGEEAKKEAEEKAKEEAEEVAE EEAEKEPQDWAETKEEPEAEAEAASSGVPATKQHPEVQV EDTDADSCPLMAEENPPSTVLPPPSPAKSDTLIVPSSAS GTHRKKLPSEDDEAEELKALSPAESPVVAWSDPTTPKDT DGQDRAASTASTNSAIINDRLQELVKLFKERTEKVKEKL IDPDVTSDEESPKPSPAKKAPEPAPDTKPAEAEPVEEEH YCDMLCCKFKHRPWKKYQFPQSIDPLTNLMYVLWLFFVV MAWNWNCWLIPVRWAFPYQTPDNIHHWLLMDYLCDLIYF LDITVFQTRLQFVRGGDIITDKKDMRNNYLKSRRFKMDL LSLLPLDFLYLKVGVNPLLRLPRCLKYMAFFEFNSRLES ILSKAYVYRVIRTTAYLLYSLHLNSCLYYWASAYQGLGS THWVYDGVGNSYIRCYYFAVKTLITIGGLPDPKTLFEIV FQLLNYFTGVFAFSVMIGQMRDVVGAATAGQTYYRSCMD STVKYMNFYKIPKSVQNRVKTWYEYTWHSQGMLDESELM VQLPDKMRLDLAIDVNYNIVSKVALFQGCDRQMIFDMLK RLRSVVYLPNDYVCKKGEIGREMY

Database cross reference

RefSeq Protein accession:NP_001129111
RefSeq Protein gi:208431781

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Liver Organelles;

GO:0017071;C:intracellular cyclic nucleotide activated cation channel complex;NAS:UniProtKB.

GO-F

GO:0030552;F:cAMP binding;IEA:UniProtKB-KW. GO:0005222;F:intracellular cAMP activated cation channel activity;NAS:UniProtKB.

GO-P

GO:0007608;P:sensory perception of smell;IEA:UniProtKB-KW.

Visual_signal_transduction:_Rods