Protein basic information
| LiverAtlas Protein ID |
HuLPr15865 |
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Uniprot ID |
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Uniprot Acc |
Q9NQW8;C9JA51;Q9NRE9; |
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Protein name |
Cyclic nucleotide-gated cation channel beta-3 |
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Comment |
FUNCTION:Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficiency of the channel when coexpressed with CNGA3 (By similarity). Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones.||SUBUNIT:Heterooligomeric complex with CNGA3.||SUBCELLULAR LOCATION:Membrane; Multi-pass membrane protein.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NQW8-1; Sequence=Displayed; Name=2; IsoId=Q9NQW8-2; Sequence=VSP 009742; Note=No experimental confirmation available;||TISSUE SPECIFICITY:Expressed specifically in the retina.||DISEASE: |
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Subcellular localization |
Membrane;Multi-pass membrane protein. |
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Gene name |
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Protein sequence
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MFKSLTKVNKVKPIGENNENEQSSRRNEEGSHPSNQSQQT TAQEENKGEEKSLKTKSTPVTSEEPHTNIQDKLSKKNSS GDLTTNPDPQNAAEPTGTVPEQKEMDPGKEGPNSPQNKP PAAPVINEYADAQLHNLVKRMRQRTALYKKKLVEGDLSS PEASPQTAKPTAVPPVKESDDKPTEHYYRLLWFKVKKMP LTEYLKRIKLPNSIDSYTDRLYLLWLLLVTLAYNWNCCF IPLRLVFPYQTADNIHYWLIADIICDIIYLYDMLFIQPR LQFVRGGDIIVDSNELRKHYRTSTKFQLDVASIIPFDIC YLFFGFNPMFRANRMLKYTSFFEFNHHLESIMDKAYIYR VIRTTGYLLFILHINACVYYWASNYEGIGTTRWVYDGEG NEYLRCYYWAVRTLITIGGLPEPQTLFEIVFQLLNFFSG VFVFSSLIGQMRDVIGAATANQNYFRACMDDTIAYMNNY SIPKLVQKRVRTWYEYTWDSQRMLDESDLLKTLPTTVQL ALAIDVNFSIISKVDLFKGCDTQMIYDMLLRLKSVLYLP GDFVCKKGEIGKEMYIIKHGEVQVLGGPDGTKVLVTLKA GSVFGEISLLAAGGGNRRTANVVAHGFANLLTLDKKTLQ EILVHYPDSERILMKKARVLLKQKAKTAEATPPRKDLAL LFPPKEETPKLFKTLLGGTGKASLARLLKLKREQAAQKK ENSEGGEEEGKENEDKQKENEDKQKENEDKGKENEDKDK GREPEEKPLDRPECTASPIAVEEEPHSVRRTVLPRGTSR QSLIISMAPSAEGGEEVLTIEVKEKAKQ |
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Database cross reference |
RefSeq Protein accession:NP_061971
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Liver relevance
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HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver;French Liver;Human Fetal Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. |
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GO-F |
GO:0030553;F:cGMP binding;IEA:UniProtKB-KW. |
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GO-P |
GO:0007165;P:signal transduction;NAS:ProtInc. GO:0007601;P:visual perception;TAS:ProtInc. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
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HuLPr15865 |
PHOSPHORYLATION |
545 |
Y |
PhosphoSitePlus |
LTP |
N |
 
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HuLPr15865 |
ACETYLATION |
166 |
K |
PhosphoSitePlus |
LTP |
N |
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Pathway
| Pathway name |
