HuLPr15866

Uniprot ID

CNIH_HUMAN

Uniprot Acc

O95406;Q3SYM7;

Protein name

Protein cornichon homolog

Comment

FUNCTION:Involved in the selective transport and maturation of TGF-alpha family proteins.||SUBUNIT:Interacts with AREG immature precursor and with immature TGFA, i.e. with a prosegment and lacking full N-glycosylation, but not with the fully N-glycosylated form. In the Golgi apparatus, may form a complex with GORASP55 and transmembrane TGFA.||SUBCELLULAR LOCATION:Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane. Note=Located primarily in the ER; may cycle between the ER and the Golgi apparatus.||TISSUE SPECIFICITY:Highly expressed in heart, liver, skeletal muscle, pancreas, adrenal medulla and cortex, thyroid, testis, spleen, appendix, peripheral blood lymphocytes and bone marrow. Lower expression found in brain, placenta, lung, kidney, ovary, small intestine, stomach, lymph node, thymus and fetal liver.||SIMILARITY:Belongs to the cornichon family.

Subcellular localization

Endoplasmic reticulum membrane;Multi-pass membrane protein.Golgi apparatus membrane.

Gene name

cornichon homolog (Drosophila)

Protein sequence

MAFTFAAFCYMLALLLTAALIFFAIWHIIAFDELKTDYKN PIDQCNTLNPLVLPEYLIHAFFCVMFLCAAEWLTLGLNM PLLAYHIWRYMSRPVMSGPGLYDPTTIMNADILAYCQKE GWCKLAFYLLAFFYYLYGMIYVLVSS

Database cross reference

RefSeq Protein accession:NP_005767
RefSeq Protein gi:5031639

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Liver Organelles;

GO:0005789;C:endoplasmic reticulum membrane;IEA:UniProtKB-SubCell. GO:0000139;C:Golgi membrane;IEA:UniProtKB-SubCell. GO:0016021;C:integral to membrane;IEA:UniProtKB-KW.

GO-P

GO:0006955;P:immune response;TAS:ProtInc. GO:0035556;P:intracellular signal transduction;IEA:InterPro. GO:0016192;P:vesicle-mediated transport;IEA:UniProtKB-KW.