HuLPr15891

Uniprot ID

CNPY3_HUMAN

Uniprot Acc

Q9BT09;O15412;Q0P6I2;Q8NF54;Q8WTU8;Q9P0F2;

Protein name

Protein canopy homolog 3

Comment

FUNCTION:Required for multiple Toll-like receptor (TLR) immune responses (By similarity). Regulates maturation in the endoplasmic reticulum, subcellular distribution, cell-surface expression, and responses of multiple TLRs (By similarity). Required for both innate and adaptative immune responses (By similarity). Neccesary for TLR1 and TLR4 maturation in the endoplasmic reticulum and TLR9 traffic to the endosome/lysosome during ligand stimulation (By similarity).||SUBUNIT:Interacts with TLR1, TLR2, TLR4 and TLR9 (By similarity). Strongest interaction with TLR4 (By similarity).||SUBCELLULAR LOCATION:Endoplasmic reticulum (By similarity).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9BT09-1; Sequence=Displayed; Name=2; IsoId=Q9BT09-2; Sequence=VSP 030132, VSP 030133; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay;||SIMILARITY:Belongs to the canopy family.||SIMILARITY:C

Subcellular localization

Endoplasmic reticulum(By similarity).

Gene name

canopy 3 homolog (zebrafish)

Protein sequence

MDSMPEPASRCLLLLPLLLLLLLLLPAPELGPSQAGAEEN DWVRLPSKCEVCKYVAVELKSAFEETGKTKEVIGTGYGI LDQKASGVKYTKSDLRLIEVTETICKRLLDYSLHKERTG SNRFAKGMSETFETLHNLVHKGVKVVMDIPYELWNETSA EVADLKKQCDVLVEEFEEVIEDWYRNHQEEDLTEFLCAN HVLKGKDTSCLAEQWSGKKGDTAALGGKKSKKKSSRAKA AGGRSSSSKQRKELGGLEGDPSPEEDEGIQKASPLTHSPPDEL

Database cross reference

RefSeq Protein accession:NP_006577
RefSeq Protein gi:33942072

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Liver Organelles;

GO:0005783;C:endoplasmic reticulum;IEA:UniProtKB-SubCell.

GO-P

GO:0045087;P:innate immune response;IEA:UniProtKB-KW.

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr15891

PHOSPHORYLATION

243

S

PhosphoSitePlus

3147393

LTP

N