Protein basic information
| LiverAtlas Protein ID |
HuLPr15934 |
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Uniprot ID |
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Uniprot Acc |
P02452;O76045;P78441;Q13896;Q13902;Q13903;Q14037;Q14992;Q15176;Q15201;Q16050;Q59F64;Q7KZ30;Q7KZ34;Q8IVI5;Q8N473;Q9UML6;Q9UMM7; |
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Protein name |
Collagen alpha-1(I) chain |
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Comment |
FUNCTION:Type I collagen is a member of group I collagen (fibrillar forming collagen).||SUBUNIT:Trimers of one alpha 2(I) and two alpha 1(I) chains. Interacts with MRC2 (By similarity). Interacts with TRAM2.||INTERACTION:Q5YB85:- (xeno); NbExp=1; IntAct=EBI-982999, EBI-982988;||SUBCELLULAR LOCATION:Secreted, extracellular space, extracellular matrix (By similarity).||TISSUE SPECIFICITY:Forms the fibrils of tendon, ligaments and bones. In bones the fibrils are mineralized with calcium hydroxyapatite.||PTM:Proline residues at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains. Proline residues at the second position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some of the chains.||PTM:O-linked glycan consists of a Glc-Gal disaccharide bound to the oxygen atom of a post-translationally added hydroxyl group.||DISEASE:Defects in COL1A1 are the cause of Caffey disease (CAFFD) [MIM:114000]; also known as infantile cortical |
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Subcellular localization |
Secreted, extracellular space, extracellular matrix(By similarity). |
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Gene name |
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Related liver disease name |
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Protein sequence
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MFSFVDLRLLLLLAATALLTHGQEEGQVEGQDEDIPPITC VQNGLRYHDRDVWKPEPCRICVCDNGKVLCDDVICDETK NCPGAEVPEGECCPVCPDGSESPTDQETTGVEGPKGDTG PRGPRGPAGPPGRDGIPGQPGLPGPPGPPGPPGPPGLGG NFAPQLSYGYDEKSTGGISVPGPMGPSGPRGLPGPPGAP GPQGFQGPPGEPGEPGASGPMGPRGPPGPPGKNGDDGEA GKPGRPGERGPPGPQGARGLPGTAGLPGMKGHRGFSGLD GAKGDAGPAGPKGEPGSPGENGAPGQMGPRGLPGERGRP GAPGPAGARGNDGATGAAGPPGPTGPAGPPGFPGAVGAK GEAGPQGPRGSEGPQGVRGEPGPPGPAGAAGPAGNPGAD GQPGAKGANGAPGIAGAPGFPGARGPSGPQGPGGPPGPK GNSGEPGAPGSKGDTGAKGEPGPVGVQGPPGPAGEEGKR GARGEPGPTGLPGPPGERGGPGSRGFPGADGVAGPKGPA GERGSPGPAGPKGSPGEAGRPGEAGLPGAKGLTGSPGSP GPDGKTGPPGPAGQDGRPGPPGPPGARGQAGVMGFPGPK GAAGEPGKAGERGVPGPPGAVGPAGKDGEAGAQGPPGPA GPAGERGEQGPAGSPGFQGLPGPAGPPGEAGKPGEQGVP GDLGAPGPSGARGERGFPGERGVQGPPGPAGPRGANGAP GNDGAKGDAGAPGAPGSQGAPGLQGMPGERGAAGLPGPK GDRGDAGPKGADGSPGKDGVRGLTGPIGPPGPAGAPGDK GESGPSGPAGPTGARGAPGDRGEPGPPGPAGFAGPPGAD GQPGAKGEPGDAGAKGDAGPPGPAGPAGPPGPIGNVGAP GAKGARGSAGPPGATGFPGAAGRVGPPGPSGNAGPPGPP GPAGKEGGKGPRGETGPAGRPGEVGPPGPPGPAGEKGSP GADGPAGAPGTPGPQGIAGQRGVVGLPGQRGERGFPGLP GPSGEPGKQGPSGASGERGPPGPM |
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Database cross reference |
RefSeq Protein accession:NP_000079
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Liver relevance
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HCC significant Proteins |
Yes/No |
Yes |
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Quality score |
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HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver;French Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0005584;C:collagen type I;IMP:UniProtKB. GO:0005615;C:extracellular space;IDA:BHF-UCL. GO:0005886;C:plasma membrane;EXP:Reactome. |
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GO-F |
GO:0042802;F:identical protein binding;IDA:UniProtKB. GO:0048407;F:platelet-derived growth factor binding;IDA:MGI. GO:0016563;F:transcription activator activity;IDA:UniProtKB. |
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GO-P |
GO:0007411;P: |