HuLPr15938

Uniprot ID

CO3_HUMAN

Uniprot Acc

P01024;A7E236;

Protein name

Complement C3

Comment

FUNCTION:C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates.||FUNCTION:Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.||SUBUNIT:C3 precursor is first processed by the removal of 4 Arg residues, forming two chains, beta and alpha, linked by a disulfide bond. C3 convertase activates C3 by cleaving the alpha chain, releasing C3a anaphylatoxin and generating C3b (beta chain + alpha' chain). During pregnancy, C3dg exists as a complex (probably a 2:2:2 heterohexamer) with AGT and the proform of PRG2. Interacts with CR2 and VSIG4. C3

Subcellular localization

Secreted.

Gene name

complement component 3

Related liver disease name

Hepatocellular carcinoma

Protein sequence

MGPTSGPSLLLLLLTHLPLALGSPMYSIITPNILRLESEE TMVLEAHDAQGDVPVTVTVHDFPGKKLVLSSEKTVLTPA TNHMGNVTFTIPANREFKSEKGRNKFVTVQATFGTQVVE KVVLVSLQSGYLFIQTDKTIYTPGSTVLYRIFTVNHKLL PVGRTVMVNIENPEGIPVKQDSLSSQNQLGVLPLSWDIP ELVNMGQWKIRAYYENSPQQVFSTEFEVKEYVLPSFEVI VEPTEKFYYIYNEKGLEVTITARFLYGKKVEGTAFVIFG IQDGEQRISLPESLKRIPIEDGSGEVVLSRKVLLDGVQN PRAEDLVGKSLYVSATVILHSGSDMVQAERSGIPIVTSP YQIHFTKTPKYFKPGMPFDLMVFVTNPDGSPAYRVPVAV QGEDTVQSLTQGDGVAKLSINTHPSQKPLSITVRTKKQE LSEAEQATRTMQALPYSTVGNSNNYLHLSVLRTELRPGE TLNVNFLLRMDRAHEAKIRYYTYLIMNKGRLLKAGRQVR EPGQDLVVLPLSITTDFIPSFRLVAYYTLIGASGQREVV ADSVWVDVKDSCVGSLVVKSGQSEDRQPVPGQQMTLKIE GDHGARVVLVAVDKGVFVLNKKNKLTQSKIWDVVEKADI GCTPGSGKDYAGVFSDAGLTFTSSSGQQTAQRAELQCPQ PAARRRRSVQLTEKRMDKVGKYPKELRKCCEDGMRENPM RFSCQRRTRFISLGEACKKVFLDCCNYITELRRQHARAS HLGLARSNLDEDIIAEENIVSRSEFPESWLWNVEDLKEP PKNGISTKLMNIFLKDSITTWEILAVSMSDKKGICVADP FEVTVMQDFFIDLRLPYSVVRNEQVEIRAVLYNYRQNQE LKVRVELLHNPAFCSLATTKRRHQQTVTIPPKSSLSVPY VIVPLKTGLQEVEVKAAVYHHFISDGVRKSLKVVPEGIR MNKTVAVRTLDPERLGREGVQKEDIPPADLSDQVPDTES ETRILLQGTPVAQMTEDAVDAERL

Database cross reference

RefSeq Protein accession:NP_000055
RefSeq Protein gi:115298678

HCC significant Proteins

Yes/No

Yes

Quality score

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Liver Organelles;

GO:0005615;C:extracellular space;IEA:InterPro.

GO-F

GO:0004866;F:endopeptidase inhibitor activity;IEA:InterPro. GO:0005102;F:receptor binding;TAS:ProtInc.

GO-P

GO:0006957;P:complement activation, alternative pathway;EXP:Reactome. GO:0006958;P:complement activation, classical pathway;IEA:UniProtKB-KW. GO:0007186;P:G-protein coupled receptor protein signaling pathway;TAS:ProtInc. GO:0006954;P:inflammatory respon