Protein basic information
| LiverAtlas Protein ID |
HuLPr15978 |
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Uniprot ID |
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Uniprot Acc |
Q5TAT6;A6NFR5;Q13992;Q13993;Q13994;Q13995;Q13996;Q5TAT4;Q5TAT5;Q7KZ33;Q7KZ49;Q99228;Q9NQ52; |
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Protein name |
Collagen alpha-1(XIII) chain |
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Comment |
FUNCTION:Involved in cell-matrix and cell-cell adhesion interactions that are required for normal development. May participate in the linkage between muscle fiber and basement membrane. May play a role in endochondral ossification of bone and branching morphogenesis of lung. Binds heparin.||SUBUNIT:Homotrimer; disulfide-linked. Nucleation of the type XIII collagen triple helix is likely to occur at the N-terminal region with triple helix formation proceeding from the N- to the C- terminus. Interacts with FN1, perlecan/HSPG2 and NID2.||SUBCELLULAR LOCATION:Cell membrane; Single-pass type II membrane protein.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=9; Comment=Additional isoforms seem to exist; Name=1; IsoId=Q5TAT6-1; Sequence=Displayed; Name=2; IsoId=Q5TAT6-2; Sequence=VSP 052383; Note=Gene prediction based on EST data; Name=3; IsoId=Q5TAT6-3; Sequence=VSP 052383, VSP 052386; Note=Gene prediction based on EST data; Name=4; IsoId=Q5TAT6-4; Sequence=V |
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Subcellular localization |
Cell membrane;Single-pass type II membrane protein. |
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Gene name |
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Protein sequence
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MVAERTHKAAATGARGPGELGAPGTVALVAARAERGARLP SPGSCGLLTLALCSLALSLLAHFRTAELQARVLRLEAER GEQQMETAILGRVNQLLDEKWKLHSRRRREAPKTSPGCN CPPGPPGPTGRPGLPGDKGAIGMPGRVGSPGDAGLSIIG PRGPPGQPGTRGFPGFPGPIGLDGKPGHPGPKGDMGLTG PPGQPGPQGQKGEKGQCGEYPHRECLSSMPAALRSSQII ALKLLPLLNSVRLAPPPVIKRRTFQGEQSQASIQGPPGP PGPPGPSGPLGHPGLPGPMGPPGLPGPPGPKGDPGIQGY HGRKGERGMPGMPGKHGAKGAPGIAVAGMKGEPGIPGTK GEKGAEGSPGLPGLLGQKGEKGDAGNSIGGGRGEPGPPG LPGPPGPKGEAGVDGQVGPPGQPGDKGERGAAGEQGPDG PKGSKGEPGKGEMVDYNGNINEALQEIRTLALMGPPGLP GQIGPPGAPGIPGQKGEIGLPGPPGHDGEKGPRGKPGDM GPPGPQGPPGKDGPPGVKGENGHPGSPGEKGEKGETGQA GSPGEKGEAGEKGNPGAEVPGLPGPEGPPGPPGLQGVPG PKGEAGLDGAKGEKGFQGEKGDRGPLGLPGASGLDGRPG PPGTPGPIGVPGPAGPKGERGSKGDPGMTGPTGAAGLPG LHGPPGDKGNRGERGKKGSRGPKGDKGDQGAPGLDAPCPLGEDGLPVQGCWNK |
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Database cross reference |
RefSeq Protein accession:NP_001123575
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Liver relevance
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HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0005600;C:collagen type XIII;TAS:UniProtKB. GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. |
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GO-F |
GO:0005201;F:extracellular matrix structural constituent;NAS:UniProtKB. GO:0008201;F:heparin binding;IDA:UniProtKB. GO:0005515;F:protein binding;IPI:UniProtKB. |
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GO-P |
GO:0030154;P:cell differentiation;IEA:UniProtKB-KW. GO:0016337;P:cell-cell adhesion;IEP:UniProtKB. GO:0007160;P:cell-matrix adhesion;IPI:UniProtKB. GO:0001958;P:endochondral ossification;ISS:UniProtKB. GO:0001763;P:morphogenesis of a branching structur |
Pathway
| Pathway name | |
| Pathway name |
