HuLPr15995

Uniprot ID

COGA1_HUMAN

Uniprot Acc

Q07092;Q16593;Q59F89;Q71RG9;

Protein name

Collagen alpha-1(XVI) chain

Comment

FUNCTION:Involved in mediating cell attachment and inducing integrin-mediated cellular reactions, such as cell spreading and alterations in cell morphology.||SUBUNIT:Homotrimer. Interacts with FBN1, fibronectin and integrins ITGA1/ITGB1 and ITGA2/ITGB1. Integrin ITGA1/ITGB1 binds to a unique site within COL16A1 located close to its C-terminal end between collagenous domains COL1-COL3.||SUBCELLULAR LOCATION:Secreted, extracellular space, extracellular matrix.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q07092-1; Sequence=Displayed; Name=2; IsoId=Q07092-2; Sequence=VSP 024259, VSP 024260; Note=No experimental confirmation available;||TISSUE SPECIFICITY:In papillary dermis, is a component of specialized fibrillin-1-containing microfibrils, whereas in territorial cartilage matrix, it is localized to a discrete population of thin, weakly banded collagen fibrils in association with other collagens (at protein level). In the placenta, where it is fo

Subcellular localization

Secreted, extracellular space, extracellular matrix.

Gene name

collagen, type XVI, alpha 1

Protein sequence

MWVSWAPGLWLLGLWATFGHGANTGAQCPPSQQEGLKLEH SSSLPANVTGFNLIHRLSLMKTSAIKKIRNPKGPLILRL GAAPVTQPTRRVFPRGLPEEFALVLTLLLKKHTHQKTWY LFQVTDANGYPQISLEVNSQERSLELRAQGQDGDFVSCI FPVPQLFDLRWHKLMLSVAGRVASVHVDCSSASSQPLGP RRPMRPVGHVFLGLDAEQGKPVSFDLQQVHIYCDPELVL EEGCCEILPAGCPPETSKARRDTQSNELIEINPQSEGKV YTRCFCLEEPQNSEVDAQLTGRISQKAERGAKVHQETAA DECPPCVHGARDSNVTLAPSGPKGGKGERGLPGPPGSKG EKGARGNDCVRISPDAPLQCAEGPKGEKGESGALGPSGL PGSTGEKGQKGEKGDGGIKGVPGKPGRDGRPGEICVIGP KGQKGDPGFVGPEGLAGEPGPPGLPGPPGIGLPGTPGDP GGPPGPKGDKGSSGIPGKEGPGGKPGKPGVKGEKGDPCE VCPTLPEGFQNFVGLPGKPGPKGEPGDPVPARGDPGIQG IKGEKGEPCLSCSSVVGAQHLVSSTGASGDVGSPGFGLP GLPGRAGVPGLKGEKGNFGEAGPAGSPGPPGPVGPAGIK GAKGEPCEPCPALSNLQDGDVRVVALPGPSGEKGEPGPP GFGLPGKQGKAGERGLKGQKGDAGNPGDPGTPGTTGRPG LSGEPGVQGPAGPKGEKGDGCTACPSLQGTVTDMAGRPG QPGPKGEQGPEGVGRPGKPGQPGLPGVQGPPGLKGVQGE PGPPGRGVQGPQGEPGAPGLPGIQGLPGPRGPPGPTGEK GAQGSPGVKGATGPVGPPGASVSGPPGRDGQQGQTGLRG TPGEKGPRGEKGEPGECSCPSQGDLIFSGMPGAPGLWMG SSWQPGPQGPPGIPGPPGPPGVPGLQGVPGNNGLPGQPG LTAELGSLPIEQHLLKSICGDCVQGQRAHPGYLVEKGEK GDQGIPGVPGLDNCAQCFLSLERP

Database cross reference

RefSeq Protein accession:NP_001847
RefSeq Protein gi:100913220

HLPP validation

Yes/No

Yes

Project name

Human Liver Organelles;French Liver;

GO:0005597;C:collagen type XVI;TAS:ProtInc.

GO-F

GO:0005178;F:integrin binding;IDA:UniProtKB. GO:0005198;F:structural molecule activity;IEA:InterPro.

GO-P

GO:0007155;P:cell adhesion;IDA:UniProtKB. GO:0007565;P:female pregnancy;TAS:ProtInc. GO:0007229;P:integrin-mediated signaling pathway;TAS:UniProtKB.

Integrins_in_angiogenesis

Syndecan-1-mediated_signaling_events