HuLPr16128

Uniprot ID

CP2B6_HUMAN

Uniprot Acc

P20813;Q2V565;Q9UK46;

Protein name

Cytochrome P450 2B6

Comment

FUNCTION:Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.||CATALYTIC ACTIVITY:RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O.||COFACTOR:Heme group (By similarity).||SUBCELLULAR LOCATION:Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.||TISSUE SPECIFICITY:Expressed in liver, lung and heart right ventricle.||INDUCTION:By phenobarbital.||PTM:Phosphorylation is accompanied by a decrease in enzyme activity (By similarity).||SIMILARITY:Belongs to the cytochrome P450 family.||WEB RESOURCE:Name=Cytochrome P450 Allele Nomenclature Committee; Note=CYP2B6 alleles; URL="http://www.cypalleles.ki.se/cyp2b6.htm";||WEB RESOURCE:Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/cyp2b6/";

Subcellular localization

Endoplasmic reticulum membrane;Peripheral membrane protein.Microsome membrane;Peripheral membrane protein.

Gene name

cytochrome P450, family 2, subfamily B, polypeptide 6

Protein sequence

MELSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLL GNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLC GVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANG NRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEEL RKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFL KMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVY KNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEK EKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLL MLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAV IYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLI LSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFS LGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDID LTPQECGVGKIPPTYQIRFLPR

Database cross reference

RefSeq Protein accession:NP_000758
RefSeq Protein gi:7949031

Yes/No

Yes

Evidence

Translational level from literatures

Quality score

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Liver Organelles;

GO:0005789;C:endoplasmic reticulum membrane;EXP:Reactome. GO:0005792;C:microsome;NAS:UniProtKB.

GO-F

GO:0070330;F:aromatase activity;IEA:EC. GO:0009055;F:electron carrier activity;IEA:InterPro. GO:0020037;F:heme binding;IEA:InterPro. GO:0019825;F:oxygen binding;EXP:Reactome.

GO-P

GO:0042180;P:cellular ketone metabolic process;IDA:BHF-UCL. GO:0042738;P:exogenous drug catabolic process;IDA:BHF-UCL. GO:0055114;P:oxidation-reduction process;IDA:BHF-UCL. GO:0008202;P:steroid metabolic process;IMP:BHF-UCL. GO:0006805;P:xenobiotic met

Cyclophosphamide_Pathway

Ifosfamide_Pathway