Protein basic information
| LiverAtlas Protein ID |
HuLPr16132 |
|
Uniprot ID |
|
|
Uniprot Acc |
P33261;P33259;Q8WZB1;Q8WZB2;Q9UCD4; |
|
Protein name |
Cytochrome P450 2C19 |
|
Comment |
FUNCTION:Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.||CATALYTIC ACTIVITY:(+)-(R)-limonene + NADPH + O(2) = (+)-trans- carveol + NADP(+) + H(2)O.||CATALYTIC ACTIVITY:(-)-(S)-limonene + NADPH + O(2) = (-)-trans- carveol + NADP(+) + H(2)O.||CATALYTIC ACTIVITY:(-)-(S)-limonene + NADPH + O(2) = (-)-perillyl alcohol + NADP(+) + H(2)O.||COFACTOR:Heme group (By similarity).||SUBCELLULAR LOCATION:Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.||INDUCTION:P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.||POLYMORPHISM:Genetic variation in CYP2C19 is responsible for poor drug metabolism [MIM:609535]. Individuals can be characterized as either extensive metabolizers (EM) or poor metabolizer |
|
Subcellular localization |
Endoplasmic reticulum membrane;Peripheral membrane protein.Microsome membrane;Peripheral membrane protein. |
|
Gene name |
|
|
Protein sequence
|
MDPFVVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIG NILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHG YEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGK RWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELR KTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLN LMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLK NLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKE KQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLL LKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVV HEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSL TSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSA GKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDT TPVVNGFASVPPFYQLCFIPV |
|
Database cross reference |
RefSeq Protein accession:NP_000760
|
Liver relevance
| Liver sepcificity |
Yes/No |
Yes |
|
Evidence |
UniProtein |
|
|
Quality score |
|
|
| Liver sepcificity |
Yes/No |
Yes |
|
Evidence |
Translational level from literatures |
|
|
Quality score |
|
|
|
HLPP validation |
Yes/No |
Yes |
|
Project name |
Chinese Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0005789;C:endoplasmic reticulum membrane;EXP:Reactome. GO:0005792;C:microsome;IDA:BHF-UCL. |
|
GO-F |
GO:0018675;F:(S)-limonene 6-monooxygenase activity;IEA:EC. GO:0018676;F:(S)-limonene 7-monooxygenase activity;IEA:EC. GO:0033767;F:4-hydroxyacetophenone monooxygenase activity;IEA:EC. GO:0009055;F:electron carr |