HuLPr16133

Uniprot ID

CP2D6_HUMAN

Uniprot Acc

P10635;Q16752;Q2XND6;Q2XND7;Q2XNE0;Q6B012;

Protein name

Cytochrome P450 2D6

Comment

FUNCTION:Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.||CATALYTIC ACTIVITY:RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O.||COFACTOR:Heme group.||SUBCELLULAR LOCATION:Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.||INDUCTION:By pregnancy.||POLYMORPHISM:Genetic variations in CYP2D6 are the cause of poor drug metabolism CYP2D6-related [MIM:608902]. The CYP2D6 gene is highly polymorphic. CYP2D6 activity ranges widely within a population comprising ultrarapid (UM), extensive (EM), intermediate (IM) and poor (PM) metabolizer phenotypes. UM and PM are those most at risk for treatment failure or dose-dependent drug toxicity, respectively. Of the Caucasian populations of Europe and North America, 5%-10% are of the PM phenotype and are unable

Subcellular localization

Endoplasmic reticulum membrane;Peripheral membrane protein.Microsome membrane;Peripheral membrane protein.

Gene name

cytochrome P450, family 2, subfamily D, polypeptide 6

Related liver disease name

Autoimmune hepatitis

Protein sequence

MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPL PGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVV VLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQG VFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEA ACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFE YDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPA LAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEA FLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTT LAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAH MPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPK GTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKP EAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVP TGQPRPSHHGVFAFLVSPSPYELCAVPR

Database cross reference

RefSeq Protein accession:NP_000097
RefSeq Protein gi:40805836

Yes/No

Yes

Evidence

Translational level from literatures

Quality score

GO:0005789;C:endoplasmic reticulum membrane;TAS:Reactome. GO:0005792;C:microsome;IDA:BHF-UCL. GO:0005739;C:mitochondrion;IDA:BHF-UCL.

GO-F

GO:0070330;F:aromatase activity;IEA:EC. GO:0008144;F:drug binding;IDA:BHF-UCL. GO:0009055;F:electron carrier activity;IEA:InterPro. GO:0020037;F:heme binding;IDA:UniProtKB. GO:0019825;F:oxygen binding;TAS:Reactome.

GO-P

GO:0009822;P:alkaloid catabolic process;IDA:BHF-UCL. GO:0009804;P:coumarin metabolic process;IDA:BHF-UCL. GO:0042737;P:drug catabolic process;IDA:BHF-UCL. GO:0033076;P:isoquinoline alkaloid metabolic process;IDA:BHF-UCL. GO:0016098;P:monoterpenoid meta