HuLPr16139

Uniprot ID

CP2U1_HUMAN

Uniprot Acc

Q7Z449;B2RMV7;Q96EQ6;

Protein name

Cytochrome P450 2U1

Comment

FUNCTION:Catalyzes the hydroxylation of arachidonic acid, docosahexaenoic acid and other long chain fatty acids. May modulate the arachidonic acid signaling pathway and play a role in other fatty acid signaling processes.||CATALYTIC ACTIVITY:RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O.||COFACTOR:Heme group (By similarity).||BIOPHYSICOCHEMICAL PROPERTIES:Kinetic parameters: KM=2.7 uM for arachidonic acid;||SUBCELLULAR LOCATION:Endoplasmic reticulum membrane; Multi-pass membrane protein. Microsome membrane.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q7Z449-1; Sequence=Displayed; Name=2; IsoId=Q7Z449-2; Sequence=VSP 026222, VSP 026223; Note=No experimental confirmation available;||TISSUE SPECIFICITY:Widely expressed with stronger expression in thymus, heart and cerebellum.||DEVELOPMENTAL STAGE:Expressed in fetal thymus.||SIMILARITY:Belongs to the cytochrome P450 family.

Subcellular localization

Endoplasmic reticulum membrane;Multi-pass membrane protein.Microsome membrane.

Gene name

cytochrome P450, family 2, subfamily U, polypeptide 1

Protein sequence

MSSPGPSQPPAEDPPWPARLLRAPLGLLRLDPSGGALLLC GLVALLGWSWLRRRRARGIPPGPTPWPLVGNFGHVLLPP FLRRRSWLSSRTRAAGIDPSVIGPQVLLAHLARVYGSIF SFFIGHYLVVVLSDFHSVREALVQQAEVFSDRPRVPLIS IVTKEKGVVFAHYGPVWRQQRKFSHSTLRHFGLGKLSLE PKIIEEFKYVKAEMQKHGEDPFCPFSIISNAVSNIICSL CFGQRFDYTNSEFKKMLGFMSRGLEICLNSQVLLVNICP WLYYLPFGPFKELRQIEKDITSFLKKIIKDHQESLDREN PQDFIDMYLLHMEEERKNNSNSSFDEEYLFYIIGDLFIA GTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGANRA PSLTDKAQMPYTEATIMEVQRLTVVVPLAIPHMTSENTV LQGYTIPKGTLILPNLWSVHRDPAIWEKPEDFYPNRFLD DQGQLIKKETFIPFGIGKRVCMGEQLAKMELFLMFVSLM QSFAFALPEDSKKPLLTGRFGLTLAPHPFNITISRR

Database cross reference

RefSeq Protein accession:NP_898898
RefSeq Protein gi:34098959

Yes/No

Yes

Evidence

BodyMap

Quality score

HLPP validation

Yes/No

Yes

Project name

French Liver;Human Liver Organelles;

GO:0005789;C:endoplasmic reticulum membrane;EXP:Reactome. GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. GO:0005792;C:microsome;IEA:UniProtKB-SubCell.

GO-F

GO:0070330;F:aromatase activity;IEA:EC. GO:0009055;F:electron carrier activity;IEA:InterPro. GO:0020037;F:heme binding;IEA:InterPro. GO:0019825;F:oxygen binding;EXP:Reactome.

GO-P

GO:0055114;P:oxidation-reduction process;IEA:UniProtKB-KW. GO:0006805;P:xenobiotic metabolic process;TAS:Reactome.

Arachidonic_Acid_Metabolism