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Protein basic information

LiverAtlas Protein ID

HuLPr16145

Uniprot ID

CP4AB_HUMAN

Uniprot Acc

Q02928;Q06766;Q16865;Q16866;Q5VSP8;Q86SU6;Q8IWY5;

Protein name

Cytochrome P450 4A11

Comment

FUNCTION:Catalyzes the omega- and (omega-1)-hydroxylation of various fatty acids such as laurate, myristate and palmitate. Has little activity toward prostaglandins A1 and E1. Oxidizes arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE).||CATALYTIC ACTIVITY:Octane + reduced rubredoxin + O(2) = 1-octanol + oxidized rubredoxin + H(2)O.||COFACTOR:Heme group (By similarity).||SUBCELLULAR LOCATION:Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q02928-1; Sequence=Displayed; Name=2; IsoId=Q02928-2; Sequence=VSP 034595;||TISSUE SPECIFICITY:Kidney and liver.||POLYMORPHISM:CYP4A11v seems to be a rare allelic variant of CYP4A11, it seems to be unstable and not to metabolize lauric acid.||SIMILARITY:Belongs to the cytochrome P450 family.||WEB RESOURCE:Name=Cytochrome P450 Allele Nomenclature Committee; Note=CYP4A11 alleles; URL="http://www.c

Subcellular localization

Endoplasmic reticulum membrane;Peripheral membrane protein.Microsome membrane;Peripheral membrane protein.

Gene name

cytochrome P450, family 4, subfamily A, polypeptide 11

Protein sequence

MSVSVLSPSRLLGDVSGILQAASLLILLLLLIKAVQLYLH RQWLLKALQQFPCPPSHWLFGHIQELQQDQELQRIQKWV ETFPSACPHWLWGGKVRVQLYDPDYMKVILGRSDPKSHG SYRFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKP YVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDT IMKCAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNA FHQNDTIYSLTSAGRWTHRACQLAHQHTDQVIQLRKAQL QKEGELEKIKRKRHLDFLDILLLAKMENGSILSDKDLRA EVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIH SLLGDGASITWNHLDQMPYTTMCIKEALRLYPPVPGIGR ELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEV FDPFRFAPGSAQHSHAFLPFSGGSRNCIGKQFAMNELKV ATALTLLRFELLPDPTRIPIPIARLVLKSKNGIHLRLRRLPNPCEDKDQL

Database cross reference

RefSeq Protein accession:NP_000769
RefSeq Protein gi:158937242

Liver relevance

Liver sepcificity

Yes/No

Yes

Evidence

UniProtein

Quality score

Liver sepcificity

Yes/No

Yes

Evidence

Translational level from literatures

Quality score

HLPP validation

Yes/No

Yes

Project name

French Liver;Human Liver Organelles;

Ontology annotation

GO-C

GO:0005789;C:endoplasmic reticulum membrane;EXP:Reactome. GO:0005792;C:microsome;TAS:ProtInc.

GO-F

GO:0018685;F:alkane 1-monooxygenase activity;IDA:BHF-UCL. GO:0009055;F:electron carrier activity;IEA:InterPro. GO:0020037;F:heme binding;IEA:InterPro. GO:0019825;F:ox Error!!! Error!!!Go back to the login page