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Protein basic information

LiverAtlas Protein ID

HuLPr16156

Uniprot ID

CP51A_HUMAN

Uniprot Acc

Q16850;A4D1F8;B2RAI4;B4DJ55;O00770;O00772;Q16784;Q8N1A8;Q99868;

Protein name

Lanosterol 14-alpha demethylase

Comment

FUNCTION:Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol.||CATALYTIC ACTIVITY:Obtusifoliol + 3 O(2) + 3 NADPH = 4-alpha- methyl-5-alpha-ergosta-8,14,24(28)-trien-3-beta-ol + formate + 3 NADP(+) + 4 H(2)O.||COFACTOR:Heme group (By similarity).||PATHWAY:Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol:step 1/6.||SUBCELLULAR LOCATION:Endoplasmic reticulum membrane (Potential). Microsome membrane (Potential).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q16850-1; Sequence=Displayed; Name=2; IsoId=Q16850-2; Sequence=VSP 037413; Note=No experimental confirmation available;||TISSUE SPECIFICITY:Ubiquitously expressed with highest levels in testis, ovary, adrenal, prostate, liver, kidney and lung.||SIMILARITY:Belongs to the cytochrome P450 family.||SEQUENCE CAUTION:Sequence=AAB39951.1; Type=Erroneous initiation; Sequence=AAB46356.1; Type=Erroneous initiati

Subcellular localization

Endoplasmic reticulum membrane(Potential).Microsome membrane(Potential).

Gene name

cytochrome P450, family 51, subfamily A, polypeptide 1

Related liver disease name

Hepatocellular carcinoma

Protein sequence

MLLLGLLQAGGSVLGQAMEKVTGGNLLSMLLIACAFTLSL VYLIRLAAGHLVQLPAGVKSPPYIFSPIPFLGHAIAFGK SPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDAAALLF NSKNEDLNAEDVYSRLTTPVFGKGVAYDVPNPVFLEQKK MLKSGLNIAHFKQHVSIIEKETKEYFESWGESGEKNVFE ALSELIILTASHCLHGKEIRSQLNEKVAQLYADLDGGFS HAAWLLPGWLPLPSFRRRDRAHREIKDIFYKAIQKRRQS QEKIDDILQTLLDATYKDGRPLTDDEVAGMLIGLLLAGQ HTSSTTSAWMGFFLARDKTLQKKCYLEQKTVCGENLPPL TYDQLKDLNLLDRCIKETLRLRPPIMIMMRMARTPQTVA GYTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQDN PASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRL YEFDLIDGYFPTVNYTTMIHTPENPVIRYKRRSK

Database cross reference

RefSeq Protein accession:NP_000777
RefSeq Protein gi:4503243

Liver relevance

Liver sepcificity

Yes/No

Yes

Evidence

Translational level from literatures

Quality score

HCC significant Proteins

Yes/No

Yes

Quality score

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Fetal Liver;Human Liver Organelles;

Ontology annotation

GO-C

GO:0005789;C:endoplasmic reticulum membrane;EXP:Reactome. GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. GO:0005792;C:microsome;IEA:UniProtKB-SubCell.

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