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Gene, Transcriptome, Protein, Pathway or Disease. 

Protein basic information

LiverAtlas Protein ID

HuLPr16257

Uniprot ID

CRBL2_HUMAN

Uniprot Acc

O60519;B5BUM5;

Protein name

cAMP-responsive element-binding protein-like 2

Comment

FUNCTION:May play a regulatory role in the cell cycle. Identification in a chromosomal region frequently deleted in various cancers suggests that it might act as a tumor suppressor.||SUBCELLULAR LOCATION:Nucleus (By similarity).||PTM:Phosphorylated by AMPK.||SIMILARITY:Belongs to the bZIP family. ATF subfamily.||SIMILARITY:Contains 1 bZIP domain.

Subcellular localization

Nucleus(By similarity).

Gene name

cAMP responsive element binding protein-like 2

Protein sequence

MDDSKVVGGKVKKPGKRGRKPAKIDLKAKLERSRQSAREC RARKKLRYQYLEELVSSRERAICALREELEMYKQWCMAM DQGKIPSEIKALLTGEEQNKSQQNSSRHTKAGKTDANSN SW

Database cross reference

RefSeq Protein accession:NP_001301
RefSeq Protein gi:4503035

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Fetal Liver;Human Liver Organelles;

Ontology annotation

GO-C

GO:0005634;C:nucleus;TAS:ProtInc.

GO-F

GO:0046983;F:protein dimerization activity;IEA:InterPro. GO:0043565;F:sequence-specific DNA binding;IEA:InterPro. GO:0003700;F:sequence-specific DNA binding transcription factor activity;TAS:ProtInc.

GO-P

GO:0007049;P:cell cycle;IEA:UniProtKB-KW. GO:0006355;P:regulation of transcription, DNA-dependent;IEA:UniProtKB-KW. GO:0007165;P:signal transduction;TAS:ProtInc.

Pathway

Pathway name

FSH