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Protein basic information

LiverAtlas Protein ID

HuLPr16297

Uniprot ID

CRLS1_HUMAN

Uniprot Acc

Q9UJA2;D3DW09;Q27RP0;Q69YQ5;

Protein name

Cardiolipin synthase

Comment

FUNCTION:Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.||CATALYTIC ACTIVITY:2 Phosphatidylglycerol = diphosphatidylglycerol + glycerol.||SUBCELLULAR LOCATION:Mitochondrion inner membrane; Multi-pass membrane protein.||TISSUE SPECIFICITY:Highly expressed in tissues such as heart, skeletal muscle and liver.||SIMILARITY:Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

Subcellular localization

Mitochondrion inner membrane;Multi-pass membrane protein.

Gene name

cardiolipin synthase 1

Protein sequence

MLALRVARGSWGALRGAAWAPGTRPSKRRACWALLPPVPC CLGCLAERWRLRPAALGLRLPGIGQRNHCSGAGKAAPRP AAGAGAAAEAPGGQWGPASTPSLYENPWTIPNMLSMTRI GLAPVLGYLIIEEDFNIALGVFALAGLTDLLDGFIARNW ANQRSALGSALDPLADKILISILYVSLTYADLIPVPLTY MIISRDVMLIAAVFYVRYRTLPTPRTLAKYFNPCYATAR LKPTFISKVNTAVQLILVAASLAAPVFNYADSIYLQILW CFTAFTTAASAYSYYHYGRKTVQVIKD

Database cross reference

RefSeq Protein accession:NP_001120930
RefSeq Protein gi:188536108

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Human Liver Organelles;

Ontology annotation

GO-C

GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. GO:0005743;C:mitochondrial inner membrane;IEA:UniProtKB-SubCell.

GO-F

GO:0016780;F:phosphotransferase activity, for other substituted phosphate groups;IEA:InterPro.

GO-P

GO:0008654;P:phospholipid biosynthetic process;IEA:UniProtKB-KW.

Pathway

Pathway name

Phospholipid_Biosynthesis