Protein basic information
| LiverAtlas Protein ID |
HuLPr16402 |
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Uniprot ID |
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Uniprot Acc |
O94985;A8K183;Q5SR52;Q5UE58;Q71MN0;Q8N4K9; |
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Protein name |
Calsyntenin-1 |
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Comment |
FUNCTION:Induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2- mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment, abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. The intracellular fragment AlcICD suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1- binding. May modulate calcium-mediated postsynaptic signals (By similarity).||SUBUNIT:Directly interacts with APBA2. Forms a tripartite complex with APBA2 and APP. The CTF1 chain interacts with PSEN1. The intracellular fragment AlcICD interacts with APBB1; this interaction stabilizes AlcICD metab |
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Subcellular localization |
Endoplasmic reticulum membrane;Single-pass type I membrane protein.Golgi apparatus membrane.Cell projection.Cell junction, synapse, postsynaptic cell membrane;Single-pass type I membrane protein(By similarity).Nucleus. |
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Gene name |
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Related liver disease name |
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Protein sequence
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MLRRPAPALAPAARLLLAGLLCGGGVWAARVNKHKPWLEP TYHGIVTENDNTVLLDPPLIALDKDAPLRFAESFEVTVT KEGEICGFKIHGQNVPFDAVVVDKSTGEGVIRSKEKLDC ELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDV NEYAPVFKEKSYKATVIEGKQYDSILRVEAVDADCSPQF SQICSYEIITPDVPFTVDKDGYIKNTEKLNYGKEHQYKL TVTAYDCGKKRATEDVLVKISIKPTCTPGWQGWNNRIEY EPGTGALAVFPNIHLETCDEPVASVQATVELETSHIGKG CDRDTYSEKSLHRLCGAAAGTAELLPSPSGSLNWTMGLP TDNGHDSDQVFEFNGTQAVRIPDGVVSVSPKEPFTISVW MRHGPFGRKKETILCSSDKTDMNRHHYSLYVHGCRLIFL FRQDPSEEKKYRPAEFHWKLNQVCDEEWHHYVLNVEFPS VTLYVDGTSHEPFSVTEDYPLHPSKIETQLVVGACWQEF SGVENDNETEPVTVASAGGDLHMTQFFRGNLAGLTLRSG KLADKKVIDCLYTCKEGLDLQVLEDSGRGVQIQAHPSQL VLTLEGEDLGELDKAMQHISYLNSRQFPTPGIRRLKITS TIKCFNEATCISVPPVDGYVMVLQPEEPKISLSGVHHFA RAASEFESSEGVFLFPELRIISTITREVEPEGDGAEDPT VQESLVSEEIVHDLDTCEVTVEGEELNHEQESLEVDMAR LQQKGIEVSSSELGMTFTGVDTMASYEEVLHLLRYRNWH ARSLLDRKFKLICSELNGRYISNEFKVEVNVIHTANPME HANHMAAQPQFVHPEHRSFVDLSGHNLANPHPFAVVPST ATVVIVVCVSFLVFMIILGVFRIRAAHRRTMRDQDTGKE NEMDWDDSALTITVNPMETYEDQHSSEEEEEEEEEEESE DGEEEDDITSAESESSEEEEGEQGDPQNATRQQQLEWDDSTLSY |
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Database cross reference |
RefSeq Protein accession:NP_001009566
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Liver relevance
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HCC significant Proteins |
Yes/No |
Yes |
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Quality score |
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HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0030054;C:cell junction;IEA:UniProtKB-KW. GO:0042995;C:cell projection;IEA:UniProtKB-SubCell. GO:0005789;C:endoplasmic reticulum membrane;IEA:UniProtKB-SubCell. GO:0000139;C:Golgi membrane;IEA:UniProtKB-SubCell. GO:0016021;C:integral to membrane;IEA |
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GO-F |
GO:0005509;F:calcium ion binding;IEA:InterPro. |
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GO-P |
GO:0007 |